P98170

E3 ubiquitin-protein ligase XIAP    //   UniProt Profile 

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Species

 H. sapiens

Number of Interactions

 243 / 320

Average Interaction Score

 0.895

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.972 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.972 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.972 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Integral to membrane (GO:0016021) 0.94 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.94 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

P98170

Interaction Score
1

P60484

(UniProtKB/Swiss-Prot/P) Details

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Schmidt-Lanterman incisure (GO:0043220) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Myelin sheath adaxonal region (GO:0035749) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Ribonucleoprotein complex (GO:0030529) 1 Experimental: experimental Organelle PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Experimental: experimental Organelle PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus PML body (GO:0016605) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell projection (GO:0042995) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Neuron projection (GO:0043005) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Dendritic spine (GO:0043197) 1 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Internal side of plasma membrane (GO:0009898) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Apical plasma membrane (GO:0016324) 1 Experimental: inferred from mutant phenotype GO PubMed 
Membrane Postsynaptic membrane (GO:0045211) 1 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

O95999

(UniProtKB/Swiss-Prot/P) Details

B-cell lymphoma/leukemia 10

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane T cell receptor complex (GO:0042101) 0.98 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol CBM complex (GO:0032449) 1 Unknown: non-traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Lysosome (GO:0005764) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasmic microtubule (GO:0005881) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane raft (GO:0045121) 0.98 Unknown: inferred from electronic annotation GO PubMed 
Membrane Lipopolysaccharide receptor complex (GO:0046696) 0.98 Experimental: inferred from direct assay GO PubMed 
Membrane Immunological synapse (GO:0001772) 0.98 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P62987

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-60S ribosomal protein L40

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Ribosome (GO:0005840) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 0.3 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Unknown: HDA GO PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.997 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.997 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.986 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.986 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.986 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.986 Unknown: traceable author statement GO PubMed 
Cytosol Lysosomal membrane (GO:0005765) 1 Unknown: HDA GO PubMed 
Secretory-pathway Endocytic vesicle membrane (GO:0030666) 0.986 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.902 Experimental: experimental MatrixDB PubMed 
Extracellular Host cell (GO:0043657) 0.902 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular space (GO:0005615) 0.902 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.992 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Vesicle (GO:0031982) 1 Unknown: HDA GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

DIP

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q14008

(UniProtKB/Swiss-Prot/P) Details

Cytoskeleton-associated protein 5

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleolus (GO:0005730) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleolus (GO:0005730) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Microtubule cytoskeleton (GO:0015630) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Spindle pole (GO:0000922) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Centrosome (GO:0005813) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Centrosome (GO:0005813) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Gamma-tubulin complex (GO:0000930) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Microtubule plus end (GO:0035371) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Condensed chromosome kinetochore (GO:0000777) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Kinetochore (GO:0000776) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.972 Unknown: HDA GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.972 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.972 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P02511

(UniProtKB/Swiss-Prot/P) Details

Alpha-crystallin B chain

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Cell surface (GO:0009986) 0.976 Unknown: inferred from electronic annotation GO PubMed 
Membrane Myelin sheath (GO:0043209) 0.976 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Perikaryon (GO:0043204) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.79 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: experimental Human Proteinpedia PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: experimental Organelle PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Unknown: traceable author statement GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Z disc (GO:0030018) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol M band (GO:0031430) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Microtubule cytoskeleton (GO:0015630) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Actin filament bundle (GO:0032432) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Dendritic spine (GO:0043197) 0.976 Unknown: inferred from electronic annotation GO PubMed 
Membrane Postsynaptic density (GO:0014069) 0.976 Unknown: inferred from electronic annotation GO PubMed 
Membrane Axon (GO:0030424) 0.976 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.976 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 
Membrane Synaptic membrane (GO:0097060) 0.976 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q13404

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 variant 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Ubiquitin ligase complex (GO:0000151) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Ubiquitin conjugating enzyme complex (GO:0031371) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol UBC13-UEV1A complex (GO:0035370) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 0.94 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.94 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q9Y4K3

(UniProtKB/Swiss-Prot/P) Details

TNF receptor-associated factor 6

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Lipid particle (GO:0005811) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cell cortex (GO:0005938) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleolus (GO:0005730) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.992 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.3 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.7 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 0.982 Experimental: inferred from direct assay GO PubMed 
Membrane Internal side of plasma membrane (GO:0009898) 0.982 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane CD40 receptor complex (GO:0035631) 0.982 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P98170

Interaction Score
1

Q07812

(UniProtKB/Swiss-Prot/P) Details

Apoptosis regulator BAX

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Mitochondrion Bcl-2 family protein complex (GO:0097136) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion BAX complex (GO:0097144) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Pore complex (GO:0046930) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial permeability transition pore complex (GO:0005757) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.988 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.96 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.96 Experimental: inferred from direct assay GO PubMed 
Membrane Cell periphery (GO:0071944) 0.972 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.972 Unknown: HDA GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.972 Experimental: experimental eSLDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P63000

(UniProtKB/Swiss-Prot/P) Details

Ras-related C3 botulinum toxin substrate 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytosol (GO:0005829) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleolus (GO:0005730) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.999 Unknown: traceable author statement GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Trans-Golgi network (GO:0005802) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Recycling endosome membrane (GO:0055038) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Melanosome (GO:0042470) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Secretory granule membrane (GO:0030667) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Actin filament (GO:0005884) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Ruffle membrane (GO:0032587) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Lamellipodium (GO:0030027) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Dendritic spine (GO:0043197) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.96 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.96 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental eSLDB PubMed 
Membrane Membrane (GO:0016020) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 
Membrane Focal adhesion (GO:0005925) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

O43464

(UniProtKB/Swiss-Prot/P) Details

Serine protease HTRA2, mitochondrial

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Endomembrane system (GO:0012505) 0.998 Experimental: experimental Organelle PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental Organelle PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrial intermembrane space (GO:0005758) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial membrane (GO:0031966) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Experimental: experimental Organelle PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.902 Unknown: non-traceable author statement GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.902 Experimental: experimental Organelle PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.902 Unknown: traceable author statement GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Chromatin (GO:0000785) 0.992 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.995 Experimental: inferred from direct assay GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.995 Predicted: SVM decision tree eSLDB PubMed 
Membrane Internal side of plasma membrane (GO:0009898) 0.995 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane CD40 receptor complex (GO:0035631) 0.995 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed , PubMed 

P98170

Interaction Score
1

Q9HC29

(UniProtKB/Swiss-Prot/P) Details

Nucleotide-binding oligomerization domain-containing protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Cell surface (GO:0009986) 0.992 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Signalosome (GO:0008180) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.96 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.96 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Basolateral plasma membrane (GO:0016323) 0.992 Experimental: inferred from direct assay GO PubMed 
Cytosol Vesicle (GO:0031982) 1 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID, DIP, IntAct

Interaction Source Publication:

PubMed , PubMed 

P98170

Interaction Score
1

P31751

(UniProtKB/Swiss-Prot/P) Details

RAC-beta serine/threonine-protein kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Cell cortex (GO:0005938) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Unknown: traceable author statement GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.998 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Early endosome (GO:0005769) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Membrane Ruffle membrane (GO:0032587) 0.91 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.91 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q13490

(UniProtKB/Swiss-Prot/P) Details

Baculoviral IAP repeat-containing protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.994 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.994 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Fibrillar center (GO:0001650) 0.994 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus XY body (GO:0001741) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane raft (GO:0045121) 0.937 Unknown: inferred from electronic annotation GO PubMed 
Membrane Internal side of plasma membrane (GO:0009898) 0.937 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane CD40 receptor complex (GO:0035631) 0.937 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P62979

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-40S ribosomal protein S27a

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Unknown: HDA GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Small ribosomal subunit (GO:0015935) 1 Unknown: HDA GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Cytosolic small ribosomal subunit (GO:0022627) 1 Unknown: HDA GO PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 0.3 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.994 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.994 Unknown: HDA GO PubMed 
Nucleus Nucleus (GO:0005634) 0.994 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleolus (GO:0005730) 0.994 Unknown: HDA GO PubMed 
Nucleus Nucleolus (GO:0005730) 0.994 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.994 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.931 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.931 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.931 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endocytic vesicle membrane (GO:0030666) 0.931 Unknown: traceable author statement GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: experimental Human Proteinpedia PubMed 
Extracellular Extracellular region (GO:0005576) 0.902 Experimental: experimental MatrixDB PubMed 
Extracellular Host cell (GO:0043657) 0.902 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular space (GO:0005615) 0.902 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.902 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.902 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.902 Unknown: traceable author statement GO PubMed 
Cytosol Vesicle (GO:0031982) 1 Unknown: HDA GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

DIP

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P31749

(UniProtKB/Swiss-Prot/P) Details

RAC-alpha serine/threonine-protein kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Unknown: traceable author statement GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Microtubule cytoskeleton (GO:0015630) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Microtubule cytoskeleton (GO:0015630) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Spindle (GO:0005819) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cilium basal body (GO:0036064) 1 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Experimental: inferred from direct assay GO PubMed 
Cytosol Vesicle (GO:0031982) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Cell-cell junction (GO:0005911) 0.86 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P98170

Interaction Score
1

Q9Y4G8

(UniProtKB/Swiss-Prot/P) Details

Rap guanine nucleotide exchange factor 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Neuronal cell body (GO:0043025) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.94 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.94 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Late endosome (GO:0005770) 0.96 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endocytic vesicle (GO:0030139) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Centrosome (GO:0005813) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Neuron projection (GO:0043005) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental eSLDB PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to plasma membrane (GO:0005887) 1 Unknown: non-traceable author statement GO PubMed 
Membrane Apical plasma membrane (GO:0016324) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Cell-cell junction (GO:0005911) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Tight junction (GO:0005923) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Synapse (GO:0045202) 1 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q9Y2D8

(UniProtKB/Swiss-Prot/P) Details

Afadin- and alpha-actinin-binding protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Cell leading edge (GO:0031252) 0.98 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental Human Proteinpedia PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.992 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Cilium basal body (GO:0036064) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Centriolar satellite (GO:0034451) 0.998 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 0.98 Experimental: experimental eSLDB PubMed 
Membrane Cell junction (GO:0030054) 0.98 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Cell-cell adherens junction (GO:0005913) 0.98 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P07910

(UniProtKB/Swiss-Prot/P) Details

Heterogeneous nuclear ribonucleoproteins C1/C2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Ribonucleoprotein complex (GO:0030529) 1 Experimental: experimental Organelle PubMed 
Cytosol Telomerase holoenzyme complex (GO:0005697) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Pronucleus (GO:0045120) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Spliceosomal complex (GO:0005681) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Catalytic step 2 spliceosome (GO:0071013) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Actin cytoskeleton (GO:0015629) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear chromatin (GO:0000790) 1 Unknown: HDA GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Unknown: HDA GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.86 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.86 Experimental: experimental MatrixDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

O15392

(UniProtKB/Swiss-Prot/P) Details

Baculoviral IAP repeat-containing protein 5

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Midbody (GO:0030496) 0.8 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: experimental Organelle PubMed 
Cytosol Spindle (GO:0005819) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Chromosome passenger complex (GO:0032133) 1 Predicted: inferred from physical interaction GO PubMed 
Cytosol Microtubule (GO:0005874) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Chromosome (GO:0005694) 1 Experimental: experimental Organelle PubMed 
Nucleus Nuclear chromosome (GO:0000228) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Chromosome, centromeric region (GO:0000775) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Condensed chromosome kinetochore (GO:0000777) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Intercellular bridge (GO:0045171) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed , PubMed 

P98170

Interaction Score
1

O14757

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase Chk1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Centrosome (GO:0005813) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Chromosome (GO:0005694) 1 Experimental: experimental Organelle PubMed 
Nucleus Condensed nuclear chromosome (GO:0000794) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Chromatin (GO:0000785) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Chromosome, telomeric region (GO:0000781) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular space (GO:0005615) 0.3 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q99523

(UniProtKB/Swiss-Prot/P) Details

Sortilin

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Cell surface (GO:0009986) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Coated pit (GO:0005905) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Neuronal cell body (GO:0043025) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.86 Experimental: experimental eSLDB PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Experimental: experimental eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 1 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: experimental eSLDB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi cisterna membrane (GO:0032580) 1 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endosome (GO:0005768) 1 Experimental: experimental eSLDB PubMed 
Secretory-pathway Early endosome (GO:0005769) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Lysosome (GO:0005764) 1 Experimental: experimental eSLDB PubMed 
Cytosol Lysosome (GO:0005764) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Lysosomal membrane (GO:0005765) 1 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Cytoplasmic vesicle membrane (GO:0030659) 1 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Clathrin-coated vesicle (GO:0030136) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Trans-Golgi network transport vesicle (GO:0030140) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Dendrite (GO:0030425) 1 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.94 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.94 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Vesicle (GO:0031982) 1 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

O00165

(UniProtKB/Swiss-Prot/P) Details

HCLS1-associated protein X-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Endomembrane system (GO:0012505) 0.996 Experimental: experimental Organelle PubMed 
Cytosol Sarcoplasmic reticulum (GO:0016529) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasmic mRNA processing body (GO:0000932) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cell cortex (GO:0005938) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental Organelle PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrial intermembrane space (GO:0005758) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: experimental Organelle PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.996 Unknown: traceable author statement GO PubMed 
Nucleus Transcription factor complex (GO:0005667) 0.996 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.992 Experimental: experimental eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.992 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.992 Experimental: experimental Organelle PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 0.992 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.996 Experimental: experimental Organelle PubMed 
Cytosol Actin cytoskeleton (GO:0015629) 0.996 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Lamellipodium (GO:0030027) 0.958 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.958 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.958 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P63167

(UniProtKB/Swiss-Prot/P) Details

Dynein light chain 1, cytoplasmic

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Signalosome (GO:0008180) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Tertiary granule membrane (GO:0070821) 0.3 Unknown: traceable author statement GO PubMed 
Cytosol Mitotic spindle (GO:0072686) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasmic dynein complex (GO:0005868) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Centrosome (GO:0005813) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Microtubule (GO:0005874) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Kinetochore (GO:0000776) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Cilium (GO:0005929) 0.657 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.657 Unknown: HDA GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.657 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P49841

(UniProtKB/Swiss-Prot/P) Details

Glycogen synthase kinase-3 beta

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.994 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.994 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Beta-catenin destruction complex (GO:0030877) 0.994 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.994 Unknown: traceable author statement GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.992 Unknown: traceable author statement GO PubMed 
Cytosol Centrosome (GO:0005813) 0.994 Experimental: inferred from direct assay GO PubMed 
Membrane Dendrite (GO:0030425) 0.982 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Axon (GO:0030424) 0.982 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.982 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P50570

(UniProtKB/Swiss-Prot/P) Details

Dynamin-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Midbody (GO:0030496) 0.995 Unknown: inferred from electronic annotation GO PubMed 
Membrane Photoreceptor inner segment (GO:0001917) 0.995 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Coated pit (GO:0005905) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Unknown: inferred from electronic annotation GO PubMed 
Mitochondrion Mitochondrial membrane (GO:0031966) 0.7 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.853 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.853 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.853 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.995 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.995 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.995 Unknown: traceable author statement GO PubMed 
Secretory-pathway Trans-Golgi network (GO:0005802) 0.995 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endosome (GO:0005768) 0.995 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endocytic vesicle membrane (GO:0030666) 0.995 Unknown: traceable author statement GO PubMed 
Secretory-pathway Phagocytic vesicle membrane (GO:0030670) 0.995 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Clathrin-coated endocytic vesicle (GO:0045334) 0.995 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Centrosome (GO:0005813) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Microtubule (GO:0005874) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Growth cone (GO:0030426) 0.995 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Ruffle membrane (GO:0032587) 0.995 Unknown: inferred from electronic annotation GO PubMed 
Membrane Lamellipodium (GO:0030027) 0.995 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.995 Unknown: traceable author statement GO PubMed 
Membrane Phagocytic cup (GO:0001891) 0.995 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 
Membrane Focal adhesion (GO:0005925) 0.995 Unknown: HDA GO PubMed 
Membrane Postsynaptic membrane (GO:0045211) 0.995 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P49459

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 A

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol HULC complex (GO:0033503) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.997 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.997 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear chromatin (GO:0000790) 0.997 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Chromatin (GO:0000785) 0.997 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus XY body (GO:0001741) 0.997 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P49662

(UniProtKB/Swiss-Prot/P) Details

Caspase-4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol AIM2 inflammasome complex (GO:0097169) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol NLRP3 inflammasome complex (GO:0072559) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol IPAF inflammasome complex (GO:0072557) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: inferred from direct assay GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.8 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.86 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.992 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q14790

(UniProtKB/Swiss-Prot/P) Details

Caspase-8

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cell body (GO:0044297) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Ripoptosome (GO:0097342) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.902 Unknown: traceable author statement GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.902 Experimental: experimental Organelle PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 0.902 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Death-inducing signaling complex (GO:0031264) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus CD95 death-inducing signaling complex (GO:0031265) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: experimental Organelle PubMed 
Membrane Neuron projection (GO:0043005) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane raft (GO:0045121) 0.51 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P38606

(UniProtKB/Swiss-Prot/P) Details

V-type proton ATPase catalytic subunit A

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Myelin sheath (GO:0043209) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytosol (GO:0005829) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Lysosomal membrane (GO:0005765) 1 Unknown: HDA GO PubMed 
Membrane Microvillus (GO:0005902) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Membrane Proton-transporting two-sector ATPase complex (GO:0016469) 0.999 Unknown: traceable author statement GO PubMed 
Membrane Proton-transporting two-sector ATPase complex (GO:0016469) 0.999 Experimental: experimental Organelle PubMed 
Membrane Proton-transporting V-type ATPase, V1 domain (GO:0033180) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Apical plasma membrane (GO:0016324) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q8IUD2

(UniProtKB/Swiss-Prot/P) Details

ELKS/Rab6-interacting/CAST family member 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol IkappaB kinase complex (GO:0008385) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: pTarget method LOCATE PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.86 Experimental: experimental eSLDB PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.994 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.994 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Synapse (GO:0045202) 0.994 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Presynaptic active zone (GO:0048786) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Membrane Presynaptic membrane (GO:0042734) 0.994 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P38398

(UniProtKB/Swiss-Prot/P) Details

Breast cancer type 1 susceptibility protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Ubiquitin ligase complex (GO:0000151) 0.996 Unknown: non-traceable author statement GO PubMed 
Cytosol Ubiquitin ligase complex (GO:0000151) 0.996 Experimental: experimental Organelle PubMed 
Cytosol Cytoplasm (GO:0005737) 0.996 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Unknown: traceable author statement GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus BRCA1-A complex (GO:0070531) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus BRCA1-BARD1 complex (GO:0031436) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.996 Experimental: experimental Organelle PubMed 
Cytosol Gamma-tubulin ring complex (GO:0008274) 0.996 Unknown: non-traceable author statement GO PubMed 
Nucleus Chromosome (GO:0005694) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Lateral element (GO:0000800) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q13546

(UniProtKB/Swiss-Prot/P) Details

Receptor-interacting serine/threonine-protein kinase 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Ripoptosome (GO:0097342) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: inferred from direct assay GO PubMed 
Nucleus Death-inducing signaling complex (GO:0031264) 0.8 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.3 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane raft (GO:0045121) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.972 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Receptor complex (GO:0043235) 0.972 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P26447

(UniProtKB/Swiss-Prot/P) Details

Protein S100-A4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 
Membrane Neuron projection (GO:0043005) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.51 Unknown: HDA GO PubMed 
Extracellular Extracellular space (GO:0005615) 0.51 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.972 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.972 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.999 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q9HC98

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase Nek6

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear speck (GO:0016607) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Spindle pole (GO:0000922) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Microtubule organizing center (GO:0005815) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Microtubule organizing center (GO:0005815) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Centrosome (GO:0005813) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Microtubule (GO:0005874) 1 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P0CG47

(UniProtKB/Swiss-Prot/P) Details

Polyubiquitin-B

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Neuronal cell body (GO:0043025) 0.994 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.994 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.994 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytosol (GO:0005829) 0.994 Unknown: traceable author statement GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.86 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 0.86 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.956 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.956 Unknown: HDA GO PubMed 
Nucleus Nucleus (GO:0005634) 0.956 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.956 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.657 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.657 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endocytic vesicle membrane (GO:0030666) 0.657 Unknown: traceable author statement GO PubMed 
Membrane Neuron projection (GO:0043005) 0.972 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.902 Experimental: experimental MatrixDB PubMed 
Extracellular Host cell (GO:0043657) 0.902 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular space (GO:0005615) 0.902 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.972 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.972 Unknown: traceable author statement GO PubMed 
Cytosol Vesicle (GO:0031982) 0.994 Unknown: HDA GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.994 Unknown: HDA GO PubMed 

Interaction Source Database:

DIP

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P61088

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 N

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Ubiquitin ligase complex (GO:0000151) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol UBC13-MMS2 complex (GO:0031372) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol UBC13-UEV1A complex (GO:0035370) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Fibrillar center (GO:0001650) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Fibrillar center (GO:0001650) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Unknown: traceable author statement GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P14866

(UniProtKB/Swiss-Prot/P) Details

Heterogeneous nuclear ribonucleoprotein L

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Ribonucleoprotein complex (GO:0030529) 0.999 Experimental: experimental Organelle PubMed 
Cytosol Ribonucleoprotein granule (GO:0035770) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Human Proteinpedia PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.3 Unknown: HDA GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.999 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q15717

(UniProtKB/Swiss-Prot/P) Details

ELAV-like protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasmic stress granule (GO:0010494) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleolus (GO:0005730) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q96CA5

(UniProtKB/Swiss-Prot/P) Details

Baculoviral IAP repeat-containing protein 7

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.8 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: experimental eSLDB PubMed 
Cytosol Microtubule organizing center (GO:0005815) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Microtubule organizing center (GO:0005815) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q13489

(UniProtKB/Swiss-Prot/P) Details

Baculoviral IAP repeat-containing protein 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.994 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.994 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.994 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane raft (GO:0045121) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q5SW79

(UniProtKB/Swiss-Prot/P) Details

Centrosomal protein of 170 kDa

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: pTarget method LOCATE PubMed 
Cytosol Spindle (GO:0005819) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Centrosome (GO:0005813) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Centrosome (GO:0005813) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Centriole (GO:0005814) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Microtubule (GO:0005874) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.96 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q9UNE7

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase CHIP

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Ubiquitin ligase complex (GO:0000151) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Ubiquitin conjugating enzyme complex (GO:0031371) 1 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nuclear inclusion body (GO:0042405) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.8 Experimental: inferred from direct assay GO PubMed 
Cytosol Z disc (GO:0030018) 1 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P00533

(UniProtKB/Swiss-Prot/P) Details

Epidermal growth factor receptor

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Membrane Cell surface (GO:0009986) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Endomembrane system (GO:0012505) 0.972 Experimental: experimental Organelle PubMed 
Cytosol Cytoplasm (GO:0005737) 0.972 Experimental: inferred from direct assay GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.994 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.994 Experimental: experimental Organelle PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.994 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endosome (GO:0005768) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Early endosome membrane (GO:0031901) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Clathrin coated vesicle membrane (GO:0030665) 0.999 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular space (GO:0005615) 0.86 Unknown: non-traceable author statement GO PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane raft (GO:0045121) 1 Experimental: inferred from direct assay GO PubMed 
Membrane AP-2 adaptor complex (GO:0030122) 1 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Shc-EGFR complex (GO:0070435) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Receptor complex (GO:0043235) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Apical plasma membrane (GO:0016324) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Basolateral plasma membrane (GO:0016323) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Focal adhesion (GO:0005925) 1 Unknown: HDA GO PubMed 
Membrane Synapse (GO:0045202) 1 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

O43447

(UniProtKB/Swiss-Prot/P) Details

Peptidyl-prolyl cis-trans isomerase H

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Ribonucleoprotein complex (GO:0030529) 1 Experimental: experimental Organelle PubMed 
Cytosol U4/U6 snRNP (GO:0071001) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol U4/U6 x U5 tri-snRNP complex (GO:0046540) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.999 Unknown: traceable author statement GO PubMed 
Nucleus Nuclear speck (GO:0016607) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Spliceosomal complex (GO:0005681) 0.999 Unknown: inferred by curator GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q8N668

(UniProtKB/Swiss-Prot/P) Details

COMM domain-containing protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cul2-RING ubiquitin ligase complex (GO:0031462) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Recycling endosome (GO:0055037) 0.972 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Early endosome (GO:0005769) 0.972 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P98170

Interaction Score
1

Q9UNN5

(UniProtKB/Swiss-Prot/P) Details

FAS-associated factor 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.992 Experimental: experimental Organelle PubMed 
Cytosol Cytosol (GO:0005829) 0.992 Experimental: inferred from direct assay GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 0.992 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear envelope (GO:0005635) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus CD95 death-inducing signaling complex (GO:0031265) 1 Unknown: non-traceable author statement GO PubMed 
Secretory-pathway Cdc48p-Npl4p-Ufd1p AAA ATPase complex (GO:0034098) 0.8 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: experimental Organelle PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

O14727

(UniProtKB/Swiss-Prot/P) Details

Apoptotic protease-activating factor 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.994 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.994 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.994 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.994 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Apoptosome (GO:0043293) 0.994 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.992 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.86 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Secretory granule lumen (GO:0034774) 0.86 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.3 Unknown: traceable author statement GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.994 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P63279

(UniProtKB/Swiss-Prot/P) Details

SUMO-conjugating enzyme UBC9

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Transferase complex (GO:1990234) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.986 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.986 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.986 Unknown: traceable author statement GO PubMed 
Nucleus PML body (GO:0016605) 0.986 Experimental: inferred from direct assay GO PubMed 
Nucleus Synaptonemal complex (GO:0000795) 0.986 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q8IUQ4

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase SIAH1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.79 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Unknown: traceable author statement GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Beta-catenin destruction complex (GO:0030877) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Unknown: traceable author statement GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.94 Predicted: SVM decision tree eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.94 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.996 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Early endosome (GO:0005769) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P55212

(UniProtKB/Swiss-Prot/P) Details

Caspase-6

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.988 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q9H0E2

(UniProtKB/Swiss-Prot/P) Details

Toll-interacting protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nuclear body (GO:0016604) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endosome (GO:0005768) 0.86 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Lysosome (GO:0005764) 1 Experimental: experimental Human Proteinpedia PubMed 
Secretory-pathway Azurophil granule lumen (GO:0035578) 0.86 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.3 Unknown: traceable author statement GO PubMed 
Membrane Membrane (GO:0016020) 0.996 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Interleukin-1 receptor complex (GO:0045323) 0.996 Unknown: non-traceable author statement GO PubMed 
Membrane Interleukin-18 receptor complex (GO:0045092) 0.996 Unknown: non-traceable author statement GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P51668

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 D1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Ubiquitin ligase complex (GO:0000151) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.86 Unknown: traceable author statement GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.86 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P98170

Interaction Score
1

Q99623

(UniProtKB/Swiss-Prot/P) Details

Prohibitin-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Cell surface (GO:0009986) 0.986 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.96 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.999 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrial inner membrane (GO:0005743) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: experimental Human Proteinpedia PubMed 
Nucleus Nuclear matrix (GO:0016363) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.96 Experimental: experimental Human Proteinpedia PubMed 
Membrane Cell periphery (GO:0071944) 0.986 Experimental: inferred from direct assay GO PubMed 
Membrane Postsynaptic density (GO:0014069) 0.986 Unknown: inferred from electronic annotation GO PubMed 
Membrane Axon (GO:0030424) 0.986 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Presynaptic active zone (GO:0048786) 0.986 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

O60763

(UniProtKB/Swiss-Prot/P) Details

General vesicular transport factor p115

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Endomembrane system (GO:0012505) 1 Experimental: experimental Organelle PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Fibrillar center (GO:0001650) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Fibrillar center (GO:0001650) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: experimental Human Proteinpedia PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 1 Unknown: traceable author statement GO PubMed 
Secretory-pathway Golgi stack (GO:0005795) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway ER to Golgi transport vesicle membrane (GO:0012507) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway Transport vesicle (GO:0030133) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: experimental Human Proteinpedia PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q15843

(UniProtKB/Swiss-Prot/P) Details

NEDD8

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Experimental: experimental Organelle PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.998 Unknown: HDA GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q14653

(UniProtKB/Swiss-Prot/P) Details

Interferon regulatory factor 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.997 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P60763

(UniProtKB/Swiss-Prot/P) Details

Ras-related C3 botulinum toxin substrate 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Endomembrane system (GO:0012505) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Neuronal cell body (GO:0043025) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Filamentous actin (GO:0031941) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Cell periphery (GO:0071944) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Growth cone (GO:0030426) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Lamellipodium (GO:0030027) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Neuron projection (GO:0043005) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 1 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q14164

(UniProtKB/Swiss-Prot/P) Details

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrial membrane (GO:0031966) 0.8 Experimental: inferred from mutant phenotype GO PubMed 
Nucleus Nucleus (GO:0005634) 0.972 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.972 Unknown: traceable author statement GO PubMed 
Nucleus PML body (GO:0016605) 0.972 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.3 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P15153

(UniProtKB/Swiss-Prot/P) Details

Ras-related C3 botulinum toxin substrate 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Phagocytic vesicle membrane (GO:0030670) 0.79 Unknown: traceable author statement GO PubMed 
Cytosol Actin filament (GO:0005884) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Lamellipodium (GO:0030027) 0.98 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 0.98 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.98 Unknown: traceable author statement GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 
Membrane Focal adhesion (GO:0005925) 0.98 Unknown: HDA GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q9GZP8

(UniProtKB/Swiss-Prot/P) Details

Immortalization up-regulated protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.96 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P15374

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin carboxyl-terminal hydrolase isozyme L3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q9Y5V3

(UniProtKB/Swiss-Prot/P) Details

Melanoma-associated antigen D1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.987 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.987 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.982 Experimental: inferred from direct assay GO PubMed 
Nucleus Chromatin (GO:0000785) 0.982 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.86 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q13049

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase TRIM32

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.997 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.997 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Striated muscle myosin thick filament (GO:0005863) 0.997 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Intermediate filament cytoskeleton (GO:0045111) 0.997 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P42574

(UniProtKB/Swiss-Prot/P) Details

Caspase-3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.98 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.98 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.98 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Death-inducing signaling complex (GO:0031264) 0.98 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane raft (GO:0045121) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

HPRD, BioGRID, DIP, IntAct

Interaction Source Publication:

PubMed , PubMed , PubMed , PubMed 

P98170

Interaction Score
1

P62837

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 D2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Ubiquitin ligase complex (GO:0000151) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.86 Unknown: traceable author statement GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.86 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.998 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q12933

(UniProtKB/Swiss-Prot/P) Details

TNF receptor-associated factor 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol TRAF2-GSTP1 complex (GO:0097057) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Ubiquitin ligase complex (GO:0000151) 1 Predicted: inferred from physical interaction GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Cell cortex (GO:0005938) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.3 Unknown: traceable author statement GO PubMed 
Membrane Membrane raft (GO:0045121) 0.937 Unknown: inferred from electronic annotation GO PubMed 
Membrane Internal side of plasma membrane (GO:0009898) 0.937 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane CD40 receptor complex (GO:0035631) 0.937 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Vesicle membrane (GO:0012506) 1 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P04049

(UniProtKB/Swiss-Prot/P) Details

RAF proto-oncogene serine/threonine-protein kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.982 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.982 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.982 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.86 Experimental: experimental Organelle PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 0.86 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nuclear speck (GO:0016607) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear speck (GO:0016607) 0.988 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.7 Predicted: inferred from physical interaction GO PubMed 
Membrane Pseudopodium (GO:0031143) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P98170

Interaction Score
1

P68036

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 L3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Ubiquitin ligase complex (GO:0000151) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.972 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.972 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.972 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q96FJ2

(UniProtKB/Swiss-Prot/P) Details

Dynein light chain 2, cytoplasmic

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: unspecified method The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.657 Unknown: HDA GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.657 Unknown: unspecified method The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 0.657 Unknown: unspecified method The Human Protein Atlas PubMed 
Cytosol Cytoplasmic dynein complex (GO:0005868) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Centrosome (GO:0005813) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Myosin complex (GO:0016459) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Myosin V complex (GO:0031475) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Microtubule (GO:0005874) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Postsynaptic density (GO:0014069) 0.76 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cilium (GO:0005929) 0.76 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.76 Unknown: HDA GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.76 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q9NYJ8

(UniProtKB/Swiss-Prot/P) Details

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.79 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.3 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.86 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q96EZ8

(UniProtKB/Swiss-Prot/P) Details

Microspherule protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Perikaryon (GO:0043204) 0.982 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.982 Experimental: inferred from direct assay GO PubMed 
Cytosol Polysome (GO:0005844) 0.982 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleolus (GO:0005730) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus MLL1 complex (GO:0071339) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Histone acetyltransferase complex (GO:0000123) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Ino80 complex (GO:0031011) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Dendrite (GO:0030425) 0.7 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P55211

(UniProtKB/Swiss-Prot/P) Details

Caspase-9

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Apoptosome (GO:0043293) 0.999 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.86 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.958 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.958 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.958 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

CCSB, HPRD, BioGRID, DIP, IntAct

Interaction Source Publication:

PubMed , PubMed , PubMed , PubMed , PubMed 

P98170

Interaction Score
1

Q9Y2U5

(UniProtKB/Swiss-Prot/P) Details

Mitogen-activated protein kinase kinase kinase 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.996 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.996 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.996 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.988 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P98170

Interaction Score
1

Q92851

(UniProtKB/Swiss-Prot/P) Details

Caspase-10

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Ripoptosome (GO:0097342) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Predicted: SVM decision tree eSLDB PubMed 
Nucleus CD95 death-inducing signaling complex (GO:0031265) 0.94 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

O95835

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase LATS1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.999 Unknown: unspecified method The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.937 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.937 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.937 Unknown: unspecified method The Human Protein Atlas PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.999 Experimental: experimental eSLDB PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.999 Experimental: experimental Organelle PubMed 
Cytosol Spindle pole (GO:0000922) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Microtubule organizing center (GO:0005815) 0.999 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q9UHD2

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase TBK1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Aggresome (GO:0016235) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.3 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P98170

Interaction Score
1

O15304

(UniProtKB/Swiss-Prot/P) Details

Apoptosis regulatory protein Siva

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.987 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.987 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: experimental Organelle PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q8WVJ2

(UniProtKB/Swiss-Prot/P) Details

NudC domain-containing protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular (GO:0005622) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental Human Proteinpedia PubMed 
Nucleus Nucleus (GO:0005634) 0.958 Experimental: experimental Human Proteinpedia PubMed 
Nucleus Nucleus (GO:0005634) 0.958 Predicted: pTarget method LOCATE PubMed 
Cytosol Spindle pole (GO:0000922) 0.998 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Microtubule organizing center (GO:0005815) 0.998 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Condensed chromosome kinetochore (GO:0000777) 0.958 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q96CN9

(UniProtKB/Swiss-Prot/P) Details

GRIP and coiled-coil domain-containing protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.998 Experimental: experimental eSLDB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.998 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.998 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.992 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P55210

(UniProtKB/Swiss-Prot/P) Details

Caspase-7

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Endomembrane system (GO:0012505) 0.997 Experimental: experimental Organelle PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Unknown: traceable author statement GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.997 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 0.958 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.958 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.958 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.8 Experimental: experimental Organelle PubMed 

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed , PubMed 

P98170

Interaction Score
1

O43318

(UniProtKB/Swiss-Prot/P) Details

Mitogen-activated protein kinase kinase kinase 7

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.987 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.987 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol IkappaB kinase complex (GO:0008385) 0.987 Predicted: inferred from physical interaction GO PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Unknown: HDA GO PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Predicted: pTarget method LOCATE PubMed 
Nucleus Nuclear speck (GO:0016607) 0.997 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Ada2/Gcn5/Ada3 transcription activator complex (GO:0005671) 0.997 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.3 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P78371

(UniProtKB/Swiss-Prot/P) Details

T-complex protein 1 subunit beta

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
N/A Zona pellucida receptor complex (GO:0002199) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Membrane Myelin sheath (GO:0043209) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cell body (GO:0044297) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Chaperonin-containing T-complex (GO:0005832) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Azurophil granule lumen (GO:0035578) 0.3 Unknown: traceable author statement GO PubMed 
Cytosol Microtubule (GO:0005874) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.86 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.86 Experimental: experimental MatrixDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q9BXL8

(UniProtKB/Swiss-Prot/P) Details

Cell division cycle-associated protein 4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.996 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.996 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q17RB8

(UniProtKB/Swiss-Prot/P) Details

LON peptidase N-terminal domain and RING finger protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular (GO:0005622) 0.997 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.997 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.997 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Centrosome (GO:0005813) 0.997 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P10415

(UniProtKB/Swiss-Prot/P) Details

Apoptosis regulator Bcl-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Myelin sheath (GO:0043209) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.86 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental Organelle PubMed 
Mitochondrion Pore complex (GO:0046930) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from mutant phenotype GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.972 Experimental: experimental eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.972 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.972 Experimental: inferred from direct assay GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.972 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P0CG48

(UniProtKB/Swiss-Prot/P) Details

Polyubiquitin-C

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Myelin sheath (GO:0043209) 0.902 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.969 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.969 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytosol (GO:0005829) 0.969 Unknown: traceable author statement GO PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 0.3 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.956 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.956 Unknown: HDA GO PubMed 
Nucleus Nucleus (GO:0005634) 0.956 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.956 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.657 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.657 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endocytic vesicle membrane (GO:0030666) 0.657 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.902 Experimental: experimental MatrixDB PubMed 
Extracellular Host cell (GO:0043657) 0.902 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular space (GO:0005615) 0.902 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.902 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.902 Unknown: traceable author statement GO PubMed 
Cytosol Vesicle (GO:0031982) 0.969 Unknown: HDA GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.969 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, DIP, IntAct

Interaction Source Publication:

PubMed , PubMed , PubMed 

P98170

Interaction Score
1

P61024

(UniProtKB/Swiss-Prot/P) Details

Cyclin-dependent kinases regulatory subunit 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol SCF ubiquitin ligase complex (GO:0019005) 0.996 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytosol (GO:0005829) 0.996 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Cyclin-dependent protein kinase holoenzyme complex (GO:0000307) 0.996 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.996 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.958 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.958 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.958 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

CCSB, BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

O43353

(UniProtKB/Swiss-Prot/P) Details

Receptor-interacting serine/threonine-protein kinase 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.8 Experimental: inferred from mutant phenotype GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Vesicle (GO:0031982) 1 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID, DIP, IntAct

Interaction Source Publication:

PubMed , PubMed 

P98170

Interaction Score
1

Q9C0K7

(UniProtKB/Swiss-Prot/P) Details

STE20-related kinase adapter protein beta

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Aggresome (GO:0016235) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Aggresome (GO:0016235) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P47897

(UniProtKB/Swiss-Prot/P) Details

Glutamine--tRNA ligase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Aminoacyl-tRNA synthetase multienzyme complex (GO:0017101) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial matrix (GO:0005759) 0.3 Unknown: traceable author statement GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.8 Experimental: inferred from mutant phenotype GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q9BZR9

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase TRIM8

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.992 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.992 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.988 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus PML body (GO:0016605) 0.988 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.7 Predicted: pTarget method LOCATE PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

Q00987

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase Mdm2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.972 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.972 Experimental: inferred from mutant phenotype GO PubMed 
Cytosol Cytosol (GO:0005829) 0.972 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleolus (GO:0005730) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear body (GO:0016604) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from mutant phenotype GO PubMed 
Secretory-pathway Endocytic vesicle membrane (GO:0030666) 0.3 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.51 Unknown: traceable author statement GO PubMed 
Membrane Synapse (GO:0045202) 0.51 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P34932

(UniProtKB/Swiss-Prot/P) Details

Heat shock 70 kDa protein 4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.999 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
1

P45974

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin carboxyl-terminal hydrolase 5

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Lysosome (GO:0005764) 0.999 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

P09651

(UniProtKB/Swiss-Prot/P) Details

Heterogeneous nuclear ribonucleoprotein A1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.972 Experimental: inferred from direct assay GO PubMed 
Cytosol Ribonucleoprotein complex (GO:0030529) 0.972 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Spliceosomal complex (GO:0005681) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Catalytic step 2 spliceosome (GO:0071013) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.3 Unknown: HDA GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.972 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

Q99759

(UniProtKB/Swiss-Prot/P) Details

Mitogen-activated protein kinase kinase kinase 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.987 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.987 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.982 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

O95198

(UniProtKB/Swiss-Prot/P) Details

Kelch-like protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cul3-RING ubiquitin ligase complex (GO:0031463) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Unknown: unspecified method The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.3 Unknown: unspecified method The Human Protein Atlas PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: experimental Organelle PubMed 
Cytosol Actin cytoskeleton (GO:0015629) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Ruffle (GO:0001726) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Membrane Lamellipodium (GO:0030027) 0.51 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

O14618

(UniProtKB/Swiss-Prot/P) Details

Copper chaperone for superoxide dismutase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular space (GO:0005615) 0.7 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

Q15750

(UniProtKB/Swiss-Prot/P) Details

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.988 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.988 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear speck (GO:0016607) 0.972 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear speck (GO:0016607) 0.972 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.3 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P98170

Interaction Score
0.999

Q15819

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 variant 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.98 Unknown: traceable author statement GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.98 Experimental: experimental Human Proteinpedia PubMed 
Cytosol UBC13-MMS2 complex (GO:0031372) 0.98 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.992 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.98 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

Q9Y239

(UniProtKB/Swiss-Prot/P) Details

Nucleotide-binding oligomerization domain-containing protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.997 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.997 Unknown: traceable author statement GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Apical plasma membrane (GO:0016324) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Membrane Basolateral plasma membrane (GO:0016323) 0.86 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID, DIP, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

O15067

(UniProtKB/Swiss-Prot/P) Details

Phosphoribosylformylglycinamidine synthase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.987 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.987 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

G8JLD3

(UniProtKB/TrEmbl/P) Details

ELKS/Rab6-interacting/CAST family member 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.988 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.988 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

O43236

(UniProtKB/Swiss-Prot/P) Details

Septin-4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Myelin sheath (GO:0043209) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Septin complex (GO:0031105) 0.8 Experimental: inferred from mutant phenotype GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.86 Unknown: non-traceable author statement GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.86 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Unknown: non-traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: experimental Organelle PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Sperm annulus (GO:0097227) 0.86 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

Q01094

(UniProtKB/Swiss-Prot/P) Details

Transcription factor E2F1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Mitochondrion Mitochondrion (GO:0005739) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Rb-E2F complex (GO:0035189) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Centrosome (GO:0005813) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Centrosome (GO:0005813) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear chromatin (GO:0000790) 1 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

P05455

(UniProtKB/Swiss-Prot/P) Details

Lupus La protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Ribonucleoprotein complex (GO:0030529) 0.96 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear chromosome, telomeric region (GO:0000784) 0.999 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

Q15287

(UniProtKB/Swiss-Prot/P) Details

RNA-binding protein with serine-rich domain 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
N/A ASAP complex (GO:0061574) 0.8 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.958 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.958 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.958 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear speck (GO:0016607) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Exon-exon junction complex (GO:0035145) 1 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

P23526

(UniProtKB/Swiss-Prot/P) Details

Adenosylhomocysteinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Melanosome (GO:0042470) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Membrane Neuron projection (GO:0043005) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.999 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

P46531

(UniProtKB/Swiss-Prot/P) Details

Neurogenic locus notch homolog protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus MAML1-RBP-Jkappa- ICN1 complex (GO:0002193) 0.998 Experimental: inferred from direct assay GO PubMed 
Membrane Cell surface (GO:0009986) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytosol (GO:0005829) 0.3 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: experimental Organelle PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.657 Unknown: traceable author statement GO PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.657 Unknown: traceable author statement GO PubMed 
Secretory-pathway Acrosomal vesicle (GO:0001669) 0.657 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Predicted: SVM decision tree eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Receptor complex (GO:0043235) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Apical plasma membrane (GO:0016324) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Adherens junction (GO:0005912) 1 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

Q5T6F0

(UniProtKB/Swiss-Prot/P) Details

DDB1- and CUL4-associated factor 12

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol CUL4 RING ubiquitin ligase complex (GO:0080008) 0.998 Experimental: inferred from mutant phenotype GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Centrosome (GO:0005813) 0.998 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.999

P61077

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 D3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.991 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.991 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.991 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.991 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.3 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.991 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

P51965

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 E1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Ubiquitin ligase complex (GO:0000151) 0.958 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.958 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.992 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P98170

Interaction Score
0.998

O95831

(UniProtKB/Swiss-Prot/P) Details

Apoptosis-inducing factor 1, mitochondrial

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.79 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.998 Unknown: HDA GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.998 Experimental: experimental Organelle PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Mitochondrion Mitochondrial intermembrane space (GO:0005758) 0.998 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial inner membrane (GO:0005743) 0.998 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: experimental Organelle PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

Q92835

(UniProtKB/Swiss-Prot/P) Details

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.992 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.992 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.992 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane raft (GO:0045121) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.51 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

Q96HA8

(UniProtKB/Swiss-Prot/P) Details

Protein N-terminal glutamine amidohydrolase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.982 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.982 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.982 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.94 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

P51784

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin carboxyl-terminal hydrolase 11

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.94 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.94 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Chromosome (GO:0005694) 0.998 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

O94966

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin carboxyl-terminal hydrolase 19

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.94 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.94 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.8 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.79 Predicted: SVM decision tree eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.79 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

P15170

(UniProtKB/Swiss-Prot/P) Details

Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular (GO:0005622) 1 Unknown: non-traceable author statement GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Translation release factor complex (GO:0018444) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

Q13873

(UniProtKB/Swiss-Prot/P) Details

Bone morphogenetic protein receptor type-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Cell surface (GO:0009986) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Neuronal cell body (GO:0043025) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Dendrite (GO:0030425) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Postsynaptic density (GO:0014069) 1 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular space (GO:0005615) 0.86 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Predicted: SVM decision tree eSLDB PubMed 
Membrane Fully spanning plasma membrane (GO:0044214) 1 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Caveola (GO:0005901) 1 Experimental: inferred from mutant phenotype GO PubMed 
Membrane Integral to plasma membrane (GO:0005887) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Apical plasma membrane (GO:0016324) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Basal plasma membrane (GO:0009925) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell-cell adherens junction (GO:0005913) 1 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

Q96B02

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 W

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.958 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleolus (GO:0005730) 0.958 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.958 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

P30048

(UniProtKB/Swiss-Prot/P) Details

Thioredoxin-dependent peroxide reductase, mitochondrial

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Myelin sheath (GO:0043209) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.988 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.988 Experimental: inferred from direct assay GO PubMed 
Cytosol IkappaB kinase complex (GO:0008385) 0.988 Predicted: inferred from physical interaction GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.992 Experimental: experimental eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.992 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.992 Predicted: PAML algorithm PA-GOSUB PubMed 
Mitochondrion Mitochondrial matrix (GO:0005759) 0.992 Unknown: traceable author statement GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.8 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Early endosome (GO:0005769) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

A0A0D9SG71

(UniProtKB/TrEmbl/P) Details

Ubiquitin-conjugating enzyme E2 A

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

Q6UXS9

(UniProtKB/Swiss-Prot/P) Details

Inactive caspase-12

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol AIM2 inflammasome complex (GO:0097169) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol NLRP3 inflammasome complex (GO:0072559) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol IPAF inflammasome complex (GO:0072557) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.998

P36896

(UniProtKB/Swiss-Prot/P) Details

Activin receptor type-1B

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Cell surface (GO:0009986) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 1 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: experimental Organelle PubMed 
Membrane Integral to plasma membrane (GO:0005887) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Receptor complex (GO:0043235) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Activin receptor complex (GO:0048179) 1 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.997

P52565

(UniProtKB/Swiss-Prot/P) Details

Rho GDP-dissociation inhibitor 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.999 Experimental: experimental Organelle PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.999 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.997

O14933

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin/ISG15-conjugating enzyme E2 L6

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.987 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.987 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.987 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.79 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.79 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.997

Q08379

(UniProtKB/Swiss-Prot/P) Details

Golgin subfamily A member 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: pTarget method LOCATE PubMed 
Secretory-pathway Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116) 1 Unknown: traceable author statement GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: experimental eSLDB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi cisterna membrane (GO:0032580) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Golgi cis cisterna (GO:0000137) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 1 Unknown: traceable author statement GO PubMed 
Secretory-pathway Cis-Golgi network (GO:0005801) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway ER to Golgi transport vesicle (GO:0030134) 1 Experimental: inferred from mutant phenotype GO PubMed 
Cytosol Mitotic spindle (GO:0072686) 0.958 Experimental: inferred from direct assay GO PubMed 
Cytosol Spindle pole (GO:0000922) 0.958 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Microtubule (GO:0005874) 0.958 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.995

Q9Y572

(UniProtKB/Swiss-Prot/P) Details

Receptor-interacting serine/threonine-protein kinase 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.982 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.982 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.982 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.995

Q9Y2X8

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 D4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.982 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.982 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.982 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.994

Q9NQB0

(UniProtKB/Swiss-Prot/P) Details

Transcription factor 7-like 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Beta-catenin-TCF7L2 complex (GO:0070369) 0.8 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus PML body (GO:0016605) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Protein-DNA complex (GO:0032993) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear chromatin (GO:0000790) 1 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.994

Q04726

(UniProtKB/Swiss-Prot/P) Details

Transducin-like enhancer protein 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.8 Experimental: experimental Human Proteinpedia PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.993

Q6GPH4

(UniProtKB/Swiss-Prot/P) Details

XIAP-associated factor 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.79 Unknown: traceable author statement GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.96 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.993

P52788

(UniProtKB/Swiss-Prot/P) Details

Spermine synthase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.971 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.971 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.971 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.971 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.993

Q9Y240

(UniProtKB/Swiss-Prot/P) Details

C-type lectin domain family 11 member A

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.8 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.972 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Centrosome (GO:0005813) 0.972 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular space (GO:0005615) 0.86 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.992

Q8N9I9

(UniProtKB/Swiss-Prot/P) Details

Probable E3 ubiquitin-protein ligase DTX3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleolus (GO:0005730) 0.988 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.991

Q96P09

(UniProtKB/Swiss-Prot/P) Details

Baculoviral IAP repeat-containing protein 8

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.99

A5D8V6

(UniProtKB/Swiss-Prot/P) Details

Vacuolar protein sorting-associated protein 37C

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.958 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.958 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Late endosome membrane (GO:0031902) 0.902 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.902 Unknown: traceable author statement GO PubMed 
Secretory-pathway ESCRT I complex (GO:0000813) 0.902 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.94 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.94 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.958 Unknown: HDA GO PubMed 

Interaction Source Database:

CCSB, BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.99

A0A0C4DGE8

(UniProtKB/TrEmbl/P) Details

LON peptidase N-terminal domain and RING finger protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Centrosome (GO:0005813) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

CCSB

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.99

X6RLX0

(UniProtKB/TrEmbl/P) Details

ELKS/Rab6-interacting/CAST family member 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.989

Q9NVQ4

(UniProtKB/Swiss-Prot/P) Details

Fas apoptotic inhibitory molecule 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.958 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.958 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytosol (GO:0005829) 0.958 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.989

Q96IK5

(UniProtKB/Swiss-Prot/P) Details

Germ cell-less protein-like 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Ubiquitin ligase complex (GO:0000151) 0.7 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.991 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.991 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.991 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nuclear matrix (GO:0016363) 0.991 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.991 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.988

Q8NEA9

(UniProtKB/Swiss-Prot/P) Details

Germ cell-less protein-like 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Ubiquitin ligase complex (GO:0000151) 0.7 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.987 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.987 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.987 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nuclear matrix (GO:0016363) 0.987 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.987

P37023

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase receptor R3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Cell surface (GO:0009986) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Neuronal cell body (GO:0043025) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Lysosome (GO:0005764) 0.79 Predicted: pTarget method LOCATE PubMed 
Membrane Dendrite (GO:0030425) 1 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: experimental Organelle PubMed 
Membrane Integral to plasma membrane (GO:0005887) 1 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.986

Q96LR5

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 E2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.982 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.983

O75173

(UniProtKB/Swiss-Prot/P) Details

A disintegrin and metalloproteinase with thrombospondin motifs 4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nuclear speck (GO:0016607) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear speck (GO:0016607) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.998 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.998 Predicted: pTarget method LOCATE PubMed 
Extracellular Extracellular region (GO:0005576) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.998 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.998 Unknown: HDA GO PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.998 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.983

Q6SPF0

(UniProtKB/Swiss-Prot/P) Details

Atherin

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.983

Q9GZN4

(UniProtKB/Swiss-Prot/P) Details

Brain-specific serine protease 4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.8 Experimental: experimental eSLDB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Membrane (GO:0016020) 0.982 Experimental: experimental MatrixDB PubMed 
Membrane Extrinsic to plasma membrane (GO:0019897) 0.982 Predicted: inferred from biological aspect of ancestor GO PubMed 
Membrane Anchored to plasma membrane (GO:0046658) 0.982 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.982

Q6AZY7

(UniProtKB/Swiss-Prot/P) Details

Scavenger receptor class A member 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.999 Experimental: experimental eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.999 Experimental: experimental eSLDB PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Collagen (GO:0005581) 0.958 Unknown: inferred from electronic annotation GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.86 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.86 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.98

Q9NR28

(UniProtKB/Swiss-Prot/P) Details

Diablo homolog, mitochondrial

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.86 Experimental: experimental eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.86 Unknown: traceable author statement GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental Organelle PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrial intermembrane space (GO:0005758) 1 Unknown: traceable author statement GO PubMed 
Membrane Internal side of plasma membrane (GO:0009898) 0.91 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane CD40 receptor complex (GO:0035631) 0.91 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

HPRD, BioGRID, DIP, IntAct

Interaction Source Publication:

PubMed , PubMed , PubMed , PubMed 

P98170

Interaction Score
0.979

P57078

(UniProtKB/Swiss-Prot/P) Details

Receptor-interacting serine/threonine-protein kinase 4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.979

Q9Y6Y8

(UniProtKB/Swiss-Prot/P) Details

SEC23-interacting protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.98 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.98 Unknown: traceable author statement GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.98 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.98 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.999 Experimental: experimental eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endoplasmic reticulum-Golgi intermediate compartment (GO:0005793) 0.999 Unknown: traceable author statement GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.999 Experimental: experimental eSLDB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway ER to Golgi transport vesicle (GO:0030134) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway ER to Golgi transport vesicle membrane (GO:0012507) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.974

G3XA89

(UniProtKB/TrEmbl/P) Details

E3 ubiquitin-protein ligase Mdm2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.972

P19447

(UniProtKB/Swiss-Prot/P) Details

General transcription and DNA repair factor IIH helicase subunit XPB

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Transcription factor TFIID complex (GO:0005669) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Holo TFIIH complex (GO:0005675) 1 Unknown: traceable author statement GO PubMed 
Nucleus Core TFIIH complex (GO:0000439) 1 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

CCSB, BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.972

P40937

(UniProtKB/Swiss-Prot/P) Details

Replication factor C subunit 5

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus DNA replication factor C complex (GO:0005663) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Ctf18 RFC-like complex (GO:0031390) 1 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.972

Q9UHV2

(UniProtKB/Swiss-Prot/P) Details

SERTA domain-containing protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.987 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.987 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.987 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.987 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.971

Q5VVR7

(UniProtKB/TrEmbl/P) Details

TCF7L2 isoform pFC8A_TCF7L2_H7_ex1-11-13-13b

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.967

Q92743

(UniProtKB/Swiss-Prot/P) Details

Serine protease HTRA1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.8 Experimental: experimental eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.994 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.994 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.994 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.994 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.994 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.992 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.51 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.965

P08240

(UniProtKB/Swiss-Prot/P) Details

Signal recognition particle receptor subunit alpha

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.997 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Endomembrane system (GO:0012505) 0.86 Experimental: experimental Organelle PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.997 Predicted: pTarget method LOCATE PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.997 Experimental: experimental Organelle PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.997 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Signal recognition particle receptor complex (GO:0005785) 0.997 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.997 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: inferred from direct assay GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.86 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.957

O00238

(UniProtKB/Swiss-Prot/P) Details

Bone morphogenetic protein receptor type-1B

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Neuronal cell body (GO:0043025) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Membrane Dendrite (GO:0030425) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.999 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: experimental Organelle PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.999 Unknown: inferred by curator GO PubMed 
Membrane Receptor complex (GO:0043235) 0.999 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.956

Q8WVN8

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 Q2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.958 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.958 Unknown: traceable author statement GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.7 Predicted: pTarget method LOCATE PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.955

E5RHC2

(UniProtKB/TrEmbl/P) Details

Protein N-terminal glutamine amidohydrolase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.955

E7EPP6

(UniProtKB/TrEmbl/P) Details

Serine/threonine-protein kinase Chk1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.955

A0A087WTB8

(UniProtKB/TrEmbl/P) Details

Ubiquitin carboxyl-terminal hydrolase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.95

A0A087WW00

(UniProtKB/TrEmbl/P) Details

Ubiquitin-conjugating enzyme E2 D1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.95

D6RAH7

(UniProtKB/TrEmbl/P) Details

Ubiquitin-conjugating enzyme E2 D3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.95

E9PNS3

(UniProtKB/TrEmbl/P) Details

Toll-interacting protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.95

F2Z2Y8

(UniProtKB/TrEmbl/P) Details

Toll-interacting protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.95

A4D2P1

(UniProtKB/TrEmbl/P) Details

Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_a

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.8 Experimental: experimental eSLDB PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.95

A0A024R3B9

(UniProtKB/TrEmbl/P) Details

Alpha-crystallin B chain

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.938

Q5U5U6

(UniProtKB/TrEmbl/P) Details

Epididymis secretory protein Li 50

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.94 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.94 Experimental: experimental Human Proteinpedia PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.936

M0QYT9

(UniProtKB/TrEmbl/P) Details

Interferon regulatory factor 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: pTarget method LOCATE PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.933

Q9BQ70

(UniProtKB/Swiss-Prot/P) Details

Transcription factor 25

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.96 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.96 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.933

A0A0A0MTL7

(UniProtKB/TrEmbl/P) Details

Transcription factor 7-like 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.933

A0A0D9SGH8

(UniProtKB/TrEmbl/P) Details

Transcription factor 7-like 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.933

C6ZRJ7

(UniProtKB/TrEmbl/P) Details

TCF7L2 isoform pFC8A_TCF7L2_A3,ex1-12,13,13a

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.933

C6ZRK5

(UniProtKB/TrEmbl/P) Details

TCF7L2 isoform pFC8A_TCF7L2_ex1-11-13-14

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.933

E2GH26

(UniProtKB/TrEmbl/P) Details

T-cell factor-4 variant L

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.932

O75325

(UniProtKB/Swiss-Prot/P) Details

Leucine-rich repeat neuronal protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.996 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.996 Predicted: inferred from biological aspect of ancestor GO PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.996 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.992 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.992 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.992 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.922

Q8N2K1

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 J2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Ubiquitin ligase complex (GO:0000151) 0.7 Predicted: inferred from physical interaction GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.937 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.937 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.937 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.79 Predicted: SVM decision tree eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.79 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.908

Q7KZX8

(UniProtKB/TrEmbl/P) Details

G1 to S phase transition 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: pTarget method LOCATE PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.908

Q96FI0

(UniProtKB/TrEmbl/P) Details

UBE2W protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.908

Q8N8J5

(UniProtKB/TrEmbl/P) Details

cDNA FLJ39374 fis, clone PEBLM2008576, highly similar to Homo sapiens TOLLIP protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.904

Q8N3J5

(UniProtKB/Swiss-Prot/P) Details

Protein phosphatase 1K, mitochondrial

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.998 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.998 Experimental: experimental Human Proteinpedia PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrial matrix (GO:0005759) 0.998 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.885

Q96HN9

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: pTarget method LOCATE PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.885

Q6PRX3

(UniProtKB/TrEmbl/P) Details

Transducin-like enhancer of split 3 splice variant 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: pTarget method LOCATE PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.885

Q6FHW4

(UniProtKB/TrEmbl/P) Details

TCF7L2 protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: pTarget method LOCATE PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.884

Q5T7S2

(UniProtKB/TrEmbl/P) Details

Receptor protein serine/threonine kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.94 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.94 Predicted: pTarget method LOCATE PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.826

P02771

(UniProtKB/Swiss-Prot/P) Details

Alpha-fetoprotein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.86 Experimental: experimental eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.3 Unknown: unspecified method The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum lumen (GO:0005788) 0.86 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.808

O43909

(UniProtKB/Swiss-Prot/P) Details

Exostosin-like 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Experimental: experimental eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Experimental: experimental Human Proteinpedia PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Predicted: pTarget method LOCATE PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 1 Unknown: traceable author statement GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.86 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.86 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.799

A0A0A0MRL7

(UniProtKB/TrEmbl/P) Details

Caspase-7

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.8 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.799

B0QYN7

(UniProtKB/TrEmbl/P) Details

SUMO-conjugating enzyme UBC9

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.799

Q6FIE9

(UniProtKB/TrEmbl/P) Details

TOLLIP protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.8 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.799

J3QQX2

(UniProtKB/TrEmbl/P) Details

Rho GDP-dissociation inhibitor 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.799

A0A286YF65

(UniProtKB/TrEmbl/P) Details

Nucleotide-binding oligomerization domain-containing protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.799

A0A075B7B4

(UniProtKB/TrEmbl/P) Details

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.799

Q5ZPJ1

(UniProtKB/TrEmbl/P) Details

Bax protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.8 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.799

A8K9T9

(UniProtKB/TrEmbl/P) Details

cDNA FLJ75059, highly similar to Homo sapiens phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) (PFAS), mRNA

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.8 Experimental: experimental Human Proteinpedia PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.799

Q6FGH9

(UniProtKB/TrEmbl/P) Details

Dynein light chain

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.8 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

G3V2F7

(UniProtKB/TrEmbl/P) Details

Ubiquitin-conjugating enzyme E2 variant 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

X6REH9

(UniProtKB/TrEmbl/P) Details

Ubiquitin-conjugating enzyme E2 W

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleolus (GO:0005730) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

B7Z306

(UniProtKB/TrEmbl/P) Details

cDNA FLJ52264, highly similar to Ubiquitin-conjugating enzyme E2 E1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

J3KSZ7

(UniProtKB/TrEmbl/P) Details

Septin-4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

A7UKX8

(UniProtKB/TrEmbl/P) Details

E3 ubiquitin-protein ligase Mdm2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

J3KRN4

(UniProtKB/TrEmbl/P) Details

Mitogen-activated protein kinase kinase kinase 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

J3QRB6

(UniProtKB/TrEmbl/P) Details

Mitogen-activated protein kinase kinase kinase 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

Q59GW7

(UniProtKB/TrEmbl/P) Details

Replication factor C 5 isoform 1 variant

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.8 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

Q53SE7

(UniProtKB/TrEmbl/P) Details

Germ cell-less homolog 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.8 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

H3BMS0

(UniProtKB/TrEmbl/P) Details

RNA-binding protein with serine-rich domain 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

F5H7D6

(UniProtKB/TrEmbl/P) Details

Transducin-like enhancer protein 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.778

H0YL70

(UniProtKB/TrEmbl/P) Details

Transducin-like enhancer protein 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.752

E9PFD7

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.752

Q504U8

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.699

Q502X2

(UniProtKB/TrEmbl/P) Details

Diablo homolog

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.699

A0A0B4J1S3

(UniProtKB/TrEmbl/P) Details

Baculoviral IAP repeat-containing protein 5

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Intercellular bridge (GO:0045171) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.699

H3BLT4

(UniProtKB/TrEmbl/P) Details

Baculoviral IAP repeat-containing protein 5

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Intercellular bridge (GO:0045171) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.699

Q9UQL0

(UniProtKB/TrEmbl/P) Details

Ubiquitin-conjugating enzyme 1 isoform

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.699

Q96T11

(UniProtKB/TrEmbl/P) Details

cDNA FLJ14518 fis, clone NT2RM1000850, weakly similar to ANKYRIN R

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.699

Q9H4D1

(UniProtKB/TrEmbl/P) Details

Protein kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.699

Q1RMG2

(UniProtKB/TrEmbl/P) Details

Adenosylhomocysteinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.699

Q6P4B4

(UniProtKB/TrEmbl/P) Details

PFAS protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.699

Q6PIA0

(UniProtKB/TrEmbl/P) Details

Baculoviral IAP repeat-containing 8

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.699

Q5BKX5

(UniProtKB/Swiss-Prot/P) Details

UPF0692 protein C19orf54

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.699

Q4G0R1

(UniProtKB/TrEmbl/P) Details

PIBF1 protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.68

Q53GC0

(UniProtKB/TrEmbl/P) Details

SERTA domain containing 1 variant

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.68

Q96DS0

(UniProtKB/TrEmbl/P) Details

MDM2 variant FB55

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.68

Q6FI27

(UniProtKB/TrEmbl/P) Details

GSK3B protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.68

Q5T178

(UniProtKB/TrEmbl/P) Details

Cyclin-dependent kinases regulatory subunit

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.68

Q6NTA2

(UniProtKB/TrEmbl/P) Details

HNRNPL protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.658

A6NGS0

(UniProtKB/TrEmbl/P) Details

Ubiquitin-conjugating enzyme E2 J2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Integral to membrane (GO:0016021) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.504

B4DFZ5

(UniProtKB/TrEmbl/P) Details

cDNA FLJ60241, highly similar to Kelch-like protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.3 Unknown: unspecified method The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.3 Unknown: unspecified method The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.504

E9PEX9

(UniProtKB/TrEmbl/P) Details

Kelch-like protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.3 Unknown: unspecified method The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.3 Unknown: unspecified method The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.292

A0A087WZT3

(UniProtKB/TrEmbl/P) Details

BolA-like protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.3 Unknown: unspecified method The Human Protein Atlas PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0.282

Q96HS1

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein phosphatase PGAM5, mitochondrial

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Mitochondrion Mitochondrion (GO:0005739) 0.992 Predicted: SVM decision tree eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.992 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 0.992 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0

F8VVS7

(UniProtKB/TrEmbl/P) Details

Caspase-9

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0

A0A024RBT2

(UniProtKB/TrEmbl/P) Details

Diablo homolog, mitochondrial

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0

A0M8W4

(UniProtKB/TrEmbl/P) Details

Ubiquitin-conjugating enzyme E2 variant 2, isoform CRA_b

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0

A8KAE3

(UniProtKB/TrEmbl/P) Details

Receptor protein serine/threonine kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0

A4D2P0

(UniProtKB/TrEmbl/P) Details

Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_e

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0

G3XAL1

(UniProtKB/TrEmbl/P) Details

Caspase recruitment domain family, member 4, isoform CRA_c

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0

B7Z2I3

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0

E7BSV0

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0

F2YGG7

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P98170

Interaction Score
0

Q9Y3E2

(UniProtKB/Swiss-Prot/P) Details

BolA-like protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015