P01036

Cystatin-S // UniProt Profile

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Species	H. sapiens
Number of Interactions	55 / 81
Average Interaction Score	0.587

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.79	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.79	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

First-Neighbour Network Visualization

Toggle Display

The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

P01036

Interaction Score

0.978

P98088

(UniProtKB/Swiss-Prot/P) Details

Mucin-5AC

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.902	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.902	Unknown: unspecified method	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	0.79	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Mucus layer (GO:0070701)	0.998	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.998	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.998	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.86	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.902	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

, PubMed

P01036

Interaction Score

0.976

Q96L92

(UniProtKB/Swiss-Prot/P) Details

Sorting nexin-27

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Retromer complex (GO:0030904)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	WASH complex (GO:0071203)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.902	Unknown: inferred by curator	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.902	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Membrane	Immunological synapse (GO:0001772)	0.8	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P01036

Interaction Score

0.971

O75752

(UniProtKB/Swiss-Prot/P) Details

UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

P01036

Interaction Score

0.965

Q8WWP7

(UniProtKB/Swiss-Prot/P) Details

GTPase IMAP family member 1

P01036

Interaction Score

0.953

Q9UHD9

(UniProtKB/Swiss-Prot/P) Details

Ubiquilin-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Autophagic vacuole (GO:0005776)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P01036

Interaction Score

0.949

Q9NS68

(UniProtKB/Swiss-Prot/P) Details

Tumor necrosis factor receptor superfamily member 19

P01036

Interaction Score

0.946

P43628

(UniProtKB/Swiss-Prot/P) Details

Killer cell immunoglobulin-like receptor 2DL3

P01036

Interaction Score

0.943

Q9NS71

(UniProtKB/Swiss-Prot/P) Details

Gastrokine-1

P01036

Interaction Score

0.942

Q8TDY1

(UniProtKB/TrEmbl/P) Details

Hexosyltransferase

P01036

Interaction Score

0.942

Q49AT3

(UniProtKB/TrEmbl/P) Details

Hexosyltransferase

P01036

Interaction Score

0.942

Q7L9G8

(UniProtKB/TrEmbl/P) Details

Hexosyltransferase

P01036

Interaction Score

0.939

P61158

(UniProtKB/Swiss-Prot/P) Details

Actin-related protein 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Arp2/3 protein complex (GO:0005885)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	0.952	Experimental: inferred from direct assay	GO	PubMed
Membrane	Brush border (GO:0005903)	0.952	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.952	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.952	Unknown: HDA	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	0.952	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P01036

Interaction Score

0.931

P01037

(UniProtKB/Swiss-Prot/P) Details

Cystatin-SN

P01036

Interaction Score

0.931

Q8NG41

(UniProtKB/Swiss-Prot/P) Details

Neuropeptide B

P01036

Interaction Score

0.931

P55851

(UniProtKB/Swiss-Prot/P) Details

Mitochondrial uncoupling protein 2

P01036

Interaction Score

0.926

Q8TDN1

(UniProtKB/Swiss-Prot/P) Details

Potassium voltage-gated channel subfamily G member 4

P01036

Interaction Score

0.926

O00421

(UniProtKB/Swiss-Prot/P) Details

C-C chemokine receptor-like 2

P01036

Interaction Score

0.9

Q9UBX3

(UniProtKB/Swiss-Prot/P) Details

Mitochondrial dicarboxylate carrier

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: experimental	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.972	Unknown: HDA	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.972	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.91	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.91	Predicted: inferred from biological aspect of ancestor	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P01036

Interaction Score

0.899

O14949

(UniProtKB/Swiss-Prot/P) Details

Cytochrome b-c1 complex subunit 8

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: pTarget method	LOCATE	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrial respiratory chain complex III (GO:0005750)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Respiratory chain complex III (GO:0045275)	0.8	Experimental: experimental	Organelle	PubMed
Cytosol	Organelle inner membrane (GO:0019866)	0.8	Experimental: experimental	Organelle	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P01036

Interaction Score

0.875

P02794

(UniProtKB/Swiss-Prot/P) Details

Ferritin heavy chain

P01036

Interaction Score

0.848

P43631

(UniProtKB/Swiss-Prot/P) Details

Killer cell immunoglobulin-like receptor 2DS2

P01036

Interaction Score

0.844

Q3KR16

(UniProtKB/Swiss-Prot/P) Details

Pleckstrin homology domain-containing family G member 6

P01036

Interaction Score

0.804

O95714

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase HERC2

P01036

Interaction Score

0.803

Q53YU7

(UniProtKB/TrEmbl/P) Details

Foveolin

P01036

Interaction Score

0.769

Q9H8H2

(UniProtKB/Swiss-Prot/P) Details

Probable ATP-dependent RNA helicase DDX31

P01036

Interaction Score

0.732

Q9H903

(UniProtKB/Swiss-Prot/P) Details

Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2

P01036

Interaction Score

0.684

Q96J88

(UniProtKB/Swiss-Prot/P) Details

Epithelial-stromal interaction protein 1

P01036

Interaction Score

0.652

Q9UGP5

(UniProtKB/Swiss-Prot/P) Details

DNA polymerase lambda

P01036

Interaction Score

0.64

Q547S7

(UniProtKB/TrEmbl/P) Details

Potassium voltage-gated channel, subfamily G, member 4, isoform CRA_b

P01036

Interaction Score

0.64

Q32MC1

(UniProtKB/TrEmbl/P) Details

Potassium voltage-gated channel, subfamily G, member 4

P01036

Interaction Score

0.632

B3KTQ4

(UniProtKB/TrEmbl/P) Details

Hexosyltransferase

P01036

Interaction Score

0.553

O75579

(UniProtKB/TrEmbl/P) Details

Killer cell inhibitory receptor short form

P01036

Interaction Score

0.553

Q14950

(UniProtKB/TrEmbl/P) Details

Killer cell immunoglobulin-like receptor 2DS2

P01036

Interaction Score

0.49

Q7LDT3

(UniProtKB/TrEmbl/P) Details

Mucin

P01036

Interaction Score

0.458

O94844

(UniProtKB/Swiss-Prot/P) Details

Rho-related BTB domain-containing protein 1

P01036

Interaction Score

0.3

P62306

(UniProtKB/Swiss-Prot/P) Details

Small nuclear ribonucleoprotein F

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Small nuclear ribonucleoprotein complex (GO:0030532)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Small nucleolar ribonucleoprotein complex (GO:0005732)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	U1 snRNP (GO:0005685)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	U4 snRNP (GO:0005687)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	U7 snRNP (GO:0005683)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	SMN-Sm protein complex (GO:0034719)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	PICln-Sm protein complex (GO:0034715)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Methylosome (GO:0034709)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Spliceosomal complex (GO:0005681)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	U2-type catalytic step 2 spliceosome (GO:0071007)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	U12-type spliceosomal complex (GO:0005689)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Catalytic step 2 spliceosome (GO:0071013)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P01036

Interaction Score

0.3

Q8IU85

(UniProtKB/Swiss-Prot/P) Details

Calcium/calmodulin-dependent protein kinase type 1D

P01036

Interaction Score

0.287

Q8N878

(UniProtKB/Swiss-Prot/P) Details

FERM domain-containing protein 1

P01036

Interaction Score

0.273

Q14206

(UniProtKB/Swiss-Prot/P) Details

Calcipressin-2

P01036

Interaction Score

0.273

Q5SQQ7

(UniProtKB/TrEmbl/P) Details

Calcium/calmodulin-dependent protein kinase ID, isoform CRA_b

P01036

Interaction Score

0.24

P52815

(UniProtKB/Swiss-Prot/P) Details

39S ribosomal protein L12, mitochondrial

P01036

Interaction Score

0.24

A0A2R8Y8A7

(UniProtKB/TrEmbl/P) Details

Sorting nexin-27

P01036

Interaction Score

0.24

A0A2R8Y4L9

(UniProtKB/TrEmbl/P) Details

FERM domain-containing protein 1

P01036

Interaction Score

0.237

Q8IW19

(UniProtKB/Swiss-Prot/P) Details

Aprataxin and PNK-like factor

P01036

Interaction Score

0.237

Q6B0K9

(UniProtKB/Swiss-Prot/P) Details

Hemoglobin subunit mu

P01036

Interaction Score

0.21

O75461

(UniProtKB/Swiss-Prot/P) Details

Transcription factor E2F6

P01036

Interaction Score

0.21

Q9BVR0

(UniProtKB/Swiss-Prot/P) Details

Putative HERC2-like protein 3

P01036

Interaction Score

0.21

Q3SY00

(UniProtKB/Swiss-Prot/P) Details

Testis-specific protein 10-interacting protein

P01036

Interaction Score

0.09

P04179

(UniProtKB/Swiss-Prot/P) Details

Superoxide dismutase [Mn], mitochondrial

P01036

Interaction Score

0.09

Q8WUN7

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin domain-containing protein 2

P01036

Interaction Score

Q8N8L2

(UniProtKB/Swiss-Prot/P) Details

Zinc finger protein 491

P01036

Interaction Score

P43897

(UniProtKB/Swiss-Prot/P) Details

Elongation factor Ts, mitochondrial

P01036

Interaction Score

F6RGN5

(UniProtKB/TrEmbl/P) Details

Mitochondrial dicarboxylate carrier

P01036

Interaction Score

Q00403

(UniProtKB/Swiss-Prot/P) Details

Transcription initiation factor IIB

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
N/A	Transcriptional preinitiation complex (GO:0097550)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	RNA polymerase II transcription factor complex (GO:0090575)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Transcription factor TFIID complex (GO:0005669)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Protein-DNA complex (GO:0032993)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P01036

Interaction Score

Q16533

(UniProtKB/Swiss-Prot/P) Details

snRNA-activating protein complex subunit 1

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P01036

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P01036

P98088

Mucin-5AC

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036

Q96L92

Sorting nexin-27

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036

O75752

UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036

Q8WWP7

GTPase IMAP family member 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036

Q9UHD9

Ubiquilin-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036

Q9NS68

Tumor necrosis factor receptor superfamily member 19

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036

P43628

Killer cell immunoglobulin-like receptor 2DL3

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036

Q9NS71

Gastrokine-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036

Q8TDY1

Hexosyltransferase

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036

Q49AT3

Hexosyltransferase

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036

Q7L9G8

Hexosyltransferase

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036

P61158

Actin-related protein 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

P01036