P04233

HLA class II histocompatibility antigen gamma chain // UniProt Profile

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Species	H. sapiens
Number of Interactions	30 / 38
Average Interaction Score	0.973

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	NOS2-CD74 complex (GO:0035693)	0.966	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Macrophage migration inhibitory factor receptor complex (GO:0035692)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular (GO:0005622)	0.966	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.988	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.988	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	0.988	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Multivesicular body (GO:0005771)	0.988	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Vacuole (GO:0005773)	0.966	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosomal lumen (GO:0043202)	0.966	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.966	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.988	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.988	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.988	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Transport vesicle membrane (GO:0030658)	0.988	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: traceable author statement	GO	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	MHC class II protein complex (GO:0042613)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.966	Unknown: HDA	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

P04233

Interaction Score

P05067

(UniProtKB/Swiss-Prot/P) Details

Amyloid-beta A4 protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Coated pit (GO:0005905)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Apical part of cell (GO:0045177)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	eSLDB	PubMed
Nucleus	Nuclear envelope lumen (GO:0005641)	0.96	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Rough endoplasmic reticulum (GO:0005791)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Smooth endoplasmic reticulum (GO:0005790)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome lumen (GO:0031904)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle (GO:0030134)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Spindle midzone (GO:0051233)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Astrocyte projection (GO:0097449)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendritic shaft (GO:0043198)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Axon (GO:0030424)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Main axon (GO:0044304)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Ciliary rootlet (GO:0035253)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.98	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.98	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.98	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.98	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Membrane raft (GO:0045121)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Vesicle (GO:0031982)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Synapse (GO:0045202)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Presynaptic active zone (GO:0048786)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P04233

Interaction Score

P61073

(UniProtKB/Swiss-Prot/P) Details

C-X-C chemokine receptor type 4

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell leading edge (GO:0031252)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.902	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.8	Experimental: inferred from mutant phenotype	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.992	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.902	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.992	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.902	Unknown: HDA	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P04233

Interaction Score

P16070

(UniProtKB/Swiss-Prot/P) Details

CD44 antigen

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Macrophage migration inhibitory factor receptor complex (GO:0035692)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.86	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.992	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Secretory granule membrane (GO:0030667)	0.992	Unknown: traceable author statement	GO	PubMed
Membrane	Cell projection (GO:0042995)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Microvillus (GO:0005902)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Lamellipodium membrane (GO:0031258)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.86	Unknown: HDA	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct, BioGRID, HPRD

Interaction Source Publication:

PubMed

, PubMed

P04233

Interaction Score

P01903

(UniProtKB/Swiss-Prot/P) Details

HLA class II histocompatibility antigen, DR alpha chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.995	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Late endosome membrane (GO:0031902)	0.995	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.992	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Transport vesicle membrane (GO:0030658)	0.995	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	MHC class II protein complex (GO:0042613)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.999	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.992	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD, IntAct

Interaction Source Publication:

PubMed

P04233

Interaction Score

P04440

(UniProtKB/Swiss-Prot/P) Details

HLA class II histocompatibility antigen, DP beta 1 chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.999	Experimental: inferred from mutant phenotype	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.942	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.79	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.79	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Transport vesicle membrane (GO:0030658)	0.942	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.999	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Unknown: traceable author statement	GO	PubMed
Membrane	MHC class II protein complex (GO:0042613)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID, HPRD

Interaction Source Publication:

PubMed

, PubMed

P04233

Interaction Score

P15813

(UniProtKB/Swiss-Prot/P) Details

Antigen-presenting glycoprotein CD1d

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.997	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.958	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.98	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.98	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.958	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.997	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.997	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.997	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.997	Unknown: traceable author statement	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	0.997	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

P04233

Interaction Score

P01909

(UniProtKB/Swiss-Prot/P) Details

HLA class II histocompatibility antigen, DQ alpha 1 chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.983	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.937	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.983	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.937	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.937	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Transport vesicle membrane (GO:0030658)	0.983	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.996	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.996	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.996	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.996	Experimental: experimental	Organelle	PubMed
Membrane	MHC class II protein complex (GO:0042613)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.996	Unknown: non-traceable author statement	GO	PubMed

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

P04233

Interaction Score

P20036

(UniProtKB/Swiss-Prot/P) Details

HLA class II histocompatibility antigen, DP alpha 1 chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.994	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.942	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.992	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Transport vesicle membrane (GO:0030658)	0.942	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.994	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.994	Unknown: traceable author statement	GO	PubMed
Membrane	MHC class II protein complex (GO:0042613)	0.994	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.994	Unknown: non-traceable author statement	GO	PubMed

Interaction Source Database:

HPRD, IntAct

Interaction Source Publication:

PubMed

P04233

Interaction Score

P14174

(UniProtKB/Swiss-Prot/P) Details

Macrophage migration inhibitory factor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.972	Experimental: inferred from direct assay	GO	PubMed
Membrane	Myelin sheath (GO:0043209)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.996	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.996	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.79	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.988	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.988	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.988	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.972	Experimental: experimental	MatrixDB	PubMed
Cytosol	Vesicle (GO:0031982)	0.996	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.996	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, HPRD

Interaction Source Publication:

PubMed

P04233

Interaction Score

Q53R12

(UniProtKB/Swiss-Prot/P) Details

Transmembrane 4 L6 family member 20

P04233

Interaction Score

Q9Y678

(UniProtKB/Swiss-Prot/P) Details

Coatomer subunit gamma-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	0.992	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.94	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	COPI vesicle coat (GO:0030126)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Transport vesicle (GO:0030133)	0.999	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P04233

Interaction Score

P22314

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-like modifier-activating enzyme 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Rough endoplasmic reticulum membrane (GO:0030867)	0.96	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Heterochromatin (GO:0000792)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Desmosome (GO:0030057)	0.8	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P04233

Interaction Score

P0DMV8

(UniProtKB/Swiss-Prot/P) Details

Heat shock 70 kDa protein 1A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Inclusion body (GO:0016234)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Aggresome (GO:0016235)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.86	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.86	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Signalosome (GO:0008180)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.86	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.86	Experimental: experimental	Organelle	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centriole (GO:0005814)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.51	Unknown: traceable author statement	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.51	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Cytosol	Vesicle (GO:0031982)	1	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.86	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P04233

Interaction Score

P28067

(UniProtKB/Swiss-Prot/P) Details

HLA class II histocompatibility antigen, DM alpha chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.997	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.997	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Late endosome membrane (GO:0031902)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.997	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Lysosome (GO:0005764)	0.997	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.997	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.994	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.994	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	MHC class II protein complex (GO:0042613)	0.994	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P04233

Interaction Score

P01920

(UniProtKB/Swiss-Prot/P) Details

HLA class II histocompatibility antigen, DQ beta 1 chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.983	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.983	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.79	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.79	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.983	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Transport vesicle membrane (GO:0030658)	0.983	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.971	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.971	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Unknown: traceable author statement	GO	PubMed
Membrane	MHC class II protein complex (GO:0042613)	0.971	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

IntAct, HPRD

Interaction Source Publication:

PubMed

, PubMed

P04233

Interaction Score

P28068

(UniProtKB/Swiss-Prot/P) Details

HLA class II histocompatibility antigen, DM beta chain

P04233

Interaction Score

Q13404

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 variant 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Ubiquitin conjugating enzyme complex (GO:0031371)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	UBC13-UEV1A complex (GO:0035370)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.94	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	UBC13-MMS2 complex (GO:0031372)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	UBC13-UEV1A complex (GO:0035370)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Fibrillar center (GO:0001650)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Fibrillar center (GO:0001650)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

Coatomer subunit gamma

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P04233

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P04233

P05067

Amyloid-beta A4 protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233

P61073

C-X-C chemokine receptor type 4

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233

P16070

CD44 antigen

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233

P01903

HLA class II histocompatibility antigen, DR alpha chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233

P04440

HLA class II histocompatibility antigen, DP beta 1 chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233

P15813

Antigen-presenting glycoprotein CD1d

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233

P01909

HLA class II histocompatibility antigen, DQ alpha 1 chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233

P20036

HLA class II histocompatibility antigen, DP alpha 1 chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233

P14174

Macrophage migration inhibitory factor

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233

Q53R12

Transmembrane 4 L6 family member 20

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233

Q9Y678

Coatomer subunit gamma-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233

P22314

Ubiquitin-like modifier-activating enzyme 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04233