P15516

Histatin-3 // UniProt Profile

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Species	H. sapiens
Number of Interactions	27 / 37
Average Interaction Score	0.858

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.8	Experimental: experimental	eSLDB	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.3	Unknown: unspecified method	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.79	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.79	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

P15516

Interaction Score

0.993

P02788

(UniProtKB/Swiss-Prot/P) Details

Lactotransferrin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.994	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Unknown: HDA	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.86	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Phagocytic vesicle lumen (GO:0097013)	0.994	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Secretory granule (GO:0030141)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Specific granule (GO:0042581)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.997	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.997	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.997	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Other organism cell membrane (GO:0044218)	0.997	Experimental: inferred from mutant phenotype	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.997	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.96	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.972	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P15516

Interaction Score

0.993

Q9UGM3

(UniProtKB/Swiss-Prot/P) Details

Deleted in malignant brain tumors 1 protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.982	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	0.982	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Zymogen granule membrane (GO:0042589)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.971	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.971	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.971	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.971	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.988	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane (GO:0016020)	0.988	Experimental: experimental	MatrixDB	PubMed
Membrane	Extrinsic to membrane (GO:0019898)	0.988	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.972	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P15516

Interaction Score

0.986

P08123

(UniProtKB/Swiss-Prot/P) Details

Collagen alpha-2(I) chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.992	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.992	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Unknown: HDA	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Collagen type I (GO:0005584)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P15516

Interaction Score

0.985

P61626

(UniProtKB/Swiss-Prot/P) Details

Lysozyme C

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.958	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.958	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Azurophil granule lumen (GO:0035578)	0.958	Unknown: traceable author statement	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.956	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.956	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.956	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.956	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.86	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P15516

Interaction Score

0.983

P00451

(UniProtKB/Swiss-Prot/P) Details

Coagulation factor VIII

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.95	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.95	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)	0.95	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.95	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.95	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle (GO:0030134)	0.95	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.971	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.971	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.971	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.971	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.86	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P15516

Interaction Score

0.981

P11142

(UniProtKB/Swiss-Prot/P) Details

Heat shock cognate 71 kDa protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Prp19 complex (GO:0000974)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular (GO:0005622)	1	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.999	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Spliceosomal complex (GO:0005681)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosomal lumen (GO:0043202)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Melanosome (GO:0042470)	0.657	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.657	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin sculpted gamma-aminobutyric acid transport vesicle membrane (GO:0061202)	0.657	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.986	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.986	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.986	Unknown: HDA	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.986	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.986	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.931	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.931	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.931	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.931	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P15516

Interaction Score

0.974

P12273

(UniProtKB/Swiss-Prot/P) Details

Prolactin-inducible protein

P15516

Interaction Score

0.974

Q96DR5

(UniProtKB/Swiss-Prot/P) Details

BPI fold-containing family A member 2

P15516

Interaction Score

0.973

P22079

(UniProtKB/Swiss-Prot/P) Details

Lactoperoxidase

P15516

Interaction Score

0.973

Q6ZUJ8

(UniProtKB/Swiss-Prot/P) Details

Phosphoinositide 3-kinase adapter protein 1

P15516

Interaction Score

0.97

Q8TDL5

(UniProtKB/Swiss-Prot/P) Details

BPI fold-containing family B member 1

P15516

Interaction Score

0.969

P04745

(UniProtKB/Swiss-Prot/P) Details

Alpha-amylase 1

P15516

Interaction Score

0.965

P08493

(UniProtKB/Swiss-Prot/P) Details

Matrix Gla protein

P15516

Interaction Score

0.953

Q8TAX7

(UniProtKB/Swiss-Prot/P) Details

Mucin-7

P15516

Interaction Score

0.953

P23280

(UniProtKB/Swiss-Prot/P) Details

Carbonic anhydrase 6

P15516

Interaction Score

0.944

Q9UBS4

(UniProtKB/Swiss-Prot/P) Details

DnaJ homolog subfamily B member 11

P15516

Interaction Score

0.94

P02808

(UniProtKB/Swiss-Prot/P) Details

Statherin

P15516

Interaction Score

0.94

P15515

(UniProtKB/Swiss-Prot/P) Details

Histatin-1

P15516

Interaction Score

0.868

A0A024RAX0

(UniProtKB/TrEmbl/P) Details

Matrix Gla protein

P15516

Interaction Score

0.854

Q86YZ3

(UniProtKB/Swiss-Prot/P) Details

Hornerin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Keratohyalin granule (GO:0036457)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: HDA	GO	PubMed
Secretory-pathway	Azurophil granule lumen (GO:0035578)	0.3	Unknown: traceable author statement	GO	PubMed
Cytosol	Cornified envelope (GO:0001533)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.3	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Vesicle (GO:0031982)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P15516

Interaction Score

0.839

Q6NSB3

(UniProtKB/TrEmbl/P) Details

Alpha-amylase

P15516

Interaction Score

0.804

Q4KWH8

(UniProtKB/Swiss-Prot/P) Details

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

P15516

Interaction Score

0.748

P20930

(UniProtKB/Swiss-Prot/P) Details

Filaggrin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Keratohyalin granule (GO:0036457)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: HDA	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cornified envelope (GO:0001533)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intermediate filament (GO:0005882)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P15516

Interaction Score

0.64

Q2TUW9

(UniProtKB/TrEmbl/P) Details

Lactoferrin

P15516

Interaction Score

0.56

Q86YV3

(UniProtKB/TrEmbl/P) Details

FLJ00308 protein

P15516

Interaction Score

0.4

Q8IXZ2

(UniProtKB/Swiss-Prot/P) Details

Zinc finger CCCH domain-containing protein 3

P15516

Interaction Score

Q6ZSZ6

(UniProtKB/Swiss-Prot/P) Details

Teashirt homolog 1

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P15516

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P15516

P02788

Lactotransferrin

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516

Q9UGM3

Deleted in malignant brain tumors 1 protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516

P08123

Collagen alpha-2(I) chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516

P61626

Lysozyme C

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516

P00451

Coagulation factor VIII

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516

P11142

Heat shock cognate 71 kDa protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516

P12273

Prolactin-inducible protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516

Q96DR5

BPI fold-containing family A member 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516

P22079

Lactoperoxidase

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516

Q6ZUJ8

Phosphoinositide 3-kinase adapter protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516

Q8TDL5

BPI fold-containing family B member 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516

P04745

Alpha-amylase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P15516