P04745

Alpha-amylase 1 // UniProt Profile

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Species	H. sapiens
Number of Interactions	59 / 83
Average Interaction Score	0.565

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.8	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.937	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.937	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.937	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

P04745

Interaction Score

0.997

O95210

(UniProtKB/Swiss-Prot/P) Details

Starch-binding domain-containing protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.991	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Intracellular (GO:0005622)	0.999	Experimental: inferred from genetic interaction	GO	PubMed
Cytosol	Pre-autophagosomal structure membrane (GO:0034045)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.991	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.991	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.991	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Tertiary granule membrane (GO:0070821)	0.991	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Membrane	T-tubule (GO:0030315)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.999	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P04745

Interaction Score

0.987

P31323

(UniProtKB/Swiss-Prot/P) Details

cAMP-dependent protein kinase type II-beta regulatory subunit

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Neuronal cell body (GO:0043025)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	CAMP-dependent protein kinase complex (GO:0005952)	1	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Dendritic shaft (GO:0043198)	0.991	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	0.991	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Ciliary base (GO:0097546)	0.991	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane raft (GO:0045121)	0.991	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.991	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P04745

Interaction Score

0.986

O75752

(UniProtKB/Swiss-Prot/P) Details

UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

P04745

Interaction Score

0.985

Q7L8A9

(UniProtKB/Swiss-Prot/P) Details

Vasohibin-1

P04745

Interaction Score

0.982

Q9NS68

(UniProtKB/Swiss-Prot/P) Details

Tumor necrosis factor receptor superfamily member 19

P04745

Interaction Score

0.979

Q9HC84

(UniProtKB/Swiss-Prot/P) Details

Mucin-5B

P04745

Interaction Score

0.978

Q8TAX7

(UniProtKB/Swiss-Prot/P) Details

Mucin-7

P04745

Interaction Score

0.978

Q9NS71

(UniProtKB/Swiss-Prot/P) Details

Gastrokine-1

P04745

Interaction Score

0.975

P43628

(UniProtKB/Swiss-Prot/P) Details

Killer cell immunoglobulin-like receptor 2DL3

P04745

Interaction Score

0.969

P15516

(UniProtKB/Swiss-Prot/P) Details

Histatin-3

P04745

Interaction Score

0.968

Q49AT3

(UniProtKB/TrEmbl/P) Details

Hexosyltransferase

P04745

Interaction Score

0.968

Q7L9G8

(UniProtKB/TrEmbl/P) Details

Hexosyltransferase

P04745

Interaction Score

0.968

Q8TDY1

(UniProtKB/TrEmbl/P) Details

Hexosyltransferase

P04745

Interaction Score

0.959

Q8NG41

(UniProtKB/Swiss-Prot/P) Details

Neuropeptide B

P04745

Interaction Score

0.953

P55851

(UniProtKB/Swiss-Prot/P) Details

Mitochondrial uncoupling protein 2

P04745

Interaction Score

0.949

O00421

(UniProtKB/Swiss-Prot/P) Details

C-C chemokine receptor-like 2

P04745

Interaction Score

0.943

Q8WVT3

(UniProtKB/Swiss-Prot/P) Details

Trafficking protein particle complex subunit 12

P04745

Interaction Score

0.929

P43631

(UniProtKB/Swiss-Prot/P) Details

Killer cell immunoglobulin-like receptor 2DS2

P04745

Interaction Score

0.928

Q92667

(UniProtKB/Swiss-Prot/P) Details

A-kinase anchor protein 1, mitochondrial

P04745

Interaction Score

0.866

Q9Y572

(UniProtKB/Swiss-Prot/P) Details

Receptor-interacting serine/threonine-protein kinase 3

P04745

Interaction Score

0.855

O43823

(UniProtKB/Swiss-Prot/P) Details

A-kinase anchor protein 8

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Female pronucleus (GO:0001939)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nuclear matrix (GO:0016363)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Condensed chromosome (GO:0000793)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P04745

Interaction Score

0.855

Q92841

(UniProtKB/Swiss-Prot/P) Details

Probable ATP-dependent RNA helicase DDX17

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.79	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P04745

Interaction Score

0.849

Q53YU7

(UniProtKB/TrEmbl/P) Details

Foveolin

P04745

Interaction Score

0.844

Q3KR16

(UniProtKB/Swiss-Prot/P) Details

Pleckstrin homology domain-containing family G member 6

P04745

Interaction Score

0.838

Q9NNW5

(UniProtKB/Swiss-Prot/P) Details

WD repeat-containing protein 6

P04745

Interaction Score

0.75

B3KTQ4

(UniProtKB/TrEmbl/P) Details

Hexosyltransferase

P04745

Interaction Score

0.746

P53805

(UniProtKB/Swiss-Prot/P) Details

Calcipressin-1

P04745

Interaction Score

0.738

Q6ZTQ3

(UniProtKB/Swiss-Prot/P) Details

Ras association domain-containing protein 6

P04745

Interaction Score

0.726

E9PDU5

(UniProtKB/TrEmbl/P) Details

WD repeat-containing protein 6

P04745

Interaction Score

0.726

A0A087X295

(UniProtKB/TrEmbl/P) Details

WD repeat-containing protein 6

P04745

Interaction Score

0.656

Q14950

(UniProtKB/TrEmbl/P) Details

Killer cell immunoglobulin-like receptor 2DS2

P04745

Interaction Score

0.656

O75579

(UniProtKB/TrEmbl/P) Details

Killer cell inhibitory receptor short form

P04745

Interaction Score

0.458

O94844

(UniProtKB/Swiss-Prot/P) Details

Rho-related BTB domain-containing protein 1

P04745

Interaction Score

0.3

Q8IU85

(UniProtKB/Swiss-Prot/P) Details

Calcium/calmodulin-dependent protein kinase type 1D

P04745

Interaction Score

0.299

Q9H981

(UniProtKB/Swiss-Prot/P) Details

Actin-related protein 8

P04745

Interaction Score

0.298

O14519

(UniProtKB/Swiss-Prot/P) Details

Cyclin-dependent kinase 2-associated protein 1

P04745

Interaction Score

0.287

Q8N878

(UniProtKB/Swiss-Prot/P) Details

FERM domain-containing protein 1

P04745

Interaction Score

0.282

Q96S82

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-like protein 7

P04745

Interaction Score

0.273

Q5SQQ7

(UniProtKB/TrEmbl/P) Details

Calcium/calmodulin-dependent protein kinase ID, isoform CRA_b

P04745

Interaction Score

0.273

Q14206

(UniProtKB/Swiss-Prot/P) Details

Calcipressin-2

P04745

Interaction Score

0.24

Q96NZ1

(UniProtKB/Swiss-Prot/P) Details

Forkhead box protein N4

P04745

Interaction Score

0.24

V9GYW9

(UniProtKB/TrEmbl/P) Details

Calcipressin-1

P04745

Interaction Score

0.24

B3KY43

(UniProtKB/TrEmbl/P) Details

cDNA FLJ46798 fis, clone TRACH3031660, highly similar to cAMP-dependent protein kinase type II-beta regulatory subunit

P04745

Interaction Score

0.24

Q13394

(UniProtKB/Swiss-Prot/P) Details

Putative nucleotidyltransferase MAB21L1

P04745

Interaction Score

0.24

E9PDJ2

(UniProtKB/TrEmbl/P) Details

Calcipressin-1

P04745

Interaction Score

0.24

A0A2R8Y4L9

(UniProtKB/TrEmbl/P) Details

FERM domain-containing protein 1

P04745

Interaction Score

0.237

A8MT70

(UniProtKB/Swiss-Prot/P) Details

Zinc finger B-box domain-containing protein 1

P04745

Interaction Score

0.21

Q9H9M3

(UniProtKB/TrEmbl/P) Details

cDNA FLJ12657 fis, clone NT2RM4002140

P04745

Interaction Score

0.21

Q6FGP2

(UniProtKB/TrEmbl/P) Details

DSCR1 protein

P04745

Interaction Score

0.21

O75461

(UniProtKB/Swiss-Prot/P) Details

Transcription factor E2F6

P04745

Interaction Score

0.09

P04179

(UniProtKB/Swiss-Prot/P) Details

Superoxide dismutase [Mn], mitochondrial

P04745

Interaction Score

Q00403

(UniProtKB/Swiss-Prot/P) Details

Transcription initiation factor IIB

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
N/A	Transcriptional preinitiation complex (GO:0097550)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	RNA polymerase II transcription factor complex (GO:0090575)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Transcription factor TFIID complex (GO:0005669)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Protein-DNA complex (GO:0032993)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P04745

Interaction Score

A0A1W2PQ51

(UniProtKB/TrEmbl/P) Details

Probable ATP-dependent RNA helicase DDX17

P04745

Interaction Score

Q96CP5

(UniProtKB/TrEmbl/P) Details

PMPCB protein

P04745

Interaction Score

P43897

(UniProtKB/Swiss-Prot/P) Details

Elongation factor Ts, mitochondrial

P04745

Interaction Score

O75439

(UniProtKB/Swiss-Prot/P) Details

Mitochondrial-processing peptidase subunit beta

P04745

Interaction Score

Q59F66

(UniProtKB/TrEmbl/P) Details

DEAD box polypeptide 17 isoform p82 variant

P04745

Interaction Score

Q6ZMM3

(UniProtKB/TrEmbl/P) Details

cDNA FLJ16823 fis, clone UTERU2017492, highly similar to Calcipressin 1

P04745

Interaction Score

Q9UG73

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp586B1222

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P04745

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P04745

O95210

Starch-binding domain-containing protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745

P31323

cAMP-dependent protein kinase type II-beta regulatory subunit

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745

O75752

UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745

Q7L8A9

Vasohibin-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745

Q9NS68

Tumor necrosis factor receptor superfamily member 19

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745

Q9HC84

Mucin-5B

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745

Q8TAX7

Mucin-7

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745

Q9NS71

Gastrokine-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745

P43628

Killer cell immunoglobulin-like receptor 2DL3

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745

P15516

Histatin-3

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745

Q49AT3

Hexosyltransferase

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745

Q7L9G8

Hexosyltransferase

Localizations:

Interaction Source Database:

Interaction Source Publication:

P04745