P16260

Graves disease carrier protein // UniProt Profile

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Species	H. sapiens
Number of Interactions	32 / 55
Average Interaction Score	0.798

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.91	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.91	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Organelle inner membrane (GO:0019866)	0.8	Experimental: experimental	Organelle	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

P16260

Interaction Score

0.995

P01903

(UniProtKB/Swiss-Prot/P) Details

HLA class II histocompatibility antigen, DR alpha chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.995	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Late endosome membrane (GO:0031902)	0.995	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.992	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.995	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Transport vesicle membrane (GO:0030658)	0.995	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	MHC class II protein complex (GO:0042613)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.999	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.992	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P16260

Interaction Score

0.995

P20036

(UniProtKB/Swiss-Prot/P) Details

HLA class II histocompatibility antigen, DP alpha 1 chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.994	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.942	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.992	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Transport vesicle membrane (GO:0030658)	0.942	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.994	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.994	Unknown: traceable author statement	GO	PubMed
Membrane	MHC class II protein complex (GO:0042613)	0.994	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.994	Unknown: non-traceable author statement	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P16260

Interaction Score

0.995

P40259

(UniProtKB/Swiss-Prot/P) Details

B-cell antigen receptor complex-associated protein beta chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	B cell receptor complex (GO:0019815)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.971	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.971	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.971	Unknown: unspecified method	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.86	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.86	Unknown: unspecified method	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.8	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Unknown: unspecified method	The Human Protein Atlas	PubMed
Membrane	External side of plasma membrane (GO:0009897)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.971	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P16260

Interaction Score

0.994

Q96EV8

(UniProtKB/Swiss-Prot/P) Details

Dysbindin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Midbody (GO:0030496)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Sarcoplasm (GO:0016528)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	BLOC-1 complex (GO:0031083)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.7	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.956	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.956	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Melanosome membrane (GO:0033162)	0.956	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Synaptic vesicle membrane (GO:0030672)	0.956	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Growth cone (GO:0030426)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Neuron projection (GO:0043005)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Axon (GO:0030424)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Sarcolemma (GO:0042383)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic membrane (GO:0045211)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P16260

Interaction Score

0.993

P26012

(UniProtKB/Swiss-Prot/P) Details

Integrin beta-8

P16260

Interaction Score

0.992

P08247

(UniProtKB/Swiss-Prot/P) Details

Synaptophysin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	0.96	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.995	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Synaptic vesicle (GO:0008021)	0.995	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Integral to synaptic vesicle membrane (GO:0030285)	0.995	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Integral to synaptic vesicle membrane (GO:0030285)	0.995	Experimental: experimental	Organelle	PubMed
Membrane	Neuron projection (GO:0043005)	0.993	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.993	Experimental: experimental	eSLDB	PubMed
Cytosol	Vesicle (GO:0031982)	0.96	Experimental: experimental	eSLDB	PubMed
Membrane	Cell junction (GO:0030054)	0.993	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	0.993	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Excitatory synapse (GO:0060076)	0.993	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Terminal button (GO:0043195)	0.993	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Presynaptic active zone (GO:0048786)	0.993	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Presynaptic membrane (GO:0042734)	0.993	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P16260

Interaction Score

0.986

Q02297

(UniProtKB/Swiss-Prot/P) Details

Pro-neuregulin-1, membrane-bound isoform

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.8	Experimental: experimental	eSLDB	PubMed
Cytosol	Cell body (GO:0044297)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.996	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Dendrite (GO:0030425)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axolemma (GO:0030673)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.987	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Membrane (GO:0016020)	0.976	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.976	Experimental: experimental	MatrixDB	PubMed
Membrane	External side of plasma membrane (GO:0009897)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	0.976	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P16260

Interaction Score

0.97

Q9BRK5

(UniProtKB/Swiss-Prot/P) Details

45 kDa calcium-binding protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.79	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Bleb (GO:0032059)	0.853	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.853	Unknown: HDA	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.853	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.79	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P16260

Interaction Score

0.964

Q9UBP4

(UniProtKB/Swiss-Prot/P) Details

Dickkopf-related protein 3

P16260

Interaction Score

0.964

Q96KN2

(UniProtKB/Swiss-Prot/P) Details

Beta-Ala-His dipeptidase

P16260

Interaction Score

0.957

Q96CS3

(UniProtKB/Swiss-Prot/P) Details

FAS-associated factor 2

P16260

Interaction Score

0.956

P20851

(UniProtKB/Swiss-Prot/P) Details

C4b-binding protein beta chain

P16260

Interaction Score

0.954

Q15116

(UniProtKB/Swiss-Prot/P) Details

Programmed cell death protein 1

P16260

Interaction Score

0.94

Q9BV68

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase RNF126

P16260

Interaction Score

0.933

A6NFV8

(UniProtKB/TrEmbl/P) Details

Dysbindin

P16260

Interaction Score

0.923

Q96J42

(UniProtKB/Swiss-Prot/P) Details

Thioredoxin domain-containing protein 15

P16260

Interaction Score

0.922

Q8NFQ8

(UniProtKB/Swiss-Prot/P) Details

Torsin-1A-interacting protein 2

P16260

Interaction Score

0.902

Q9BUG9

(UniProtKB/TrEmbl/P) Details

Integrin beta

P16260

Interaction Score

0.902

D6RJC6

(UniProtKB/TrEmbl/P) Details

Dysbindin

P16260

Interaction Score

0.902

A0A087WYP9

(UniProtKB/TrEmbl/P) Details

Dysbindin

P16260

Interaction Score

0.868

Q7RTW5

(UniProtKB/TrEmbl/P) Details

Neuregulin 1 isoform HRG-gamma

P16260

Interaction Score

0.8

O75170

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein phosphatase 6 regulatory subunit 2

P16260

Interaction Score

0.795

O14773

(UniProtKB/Swiss-Prot/P) Details

Tripeptidyl-peptidase 1

P16260

Interaction Score

0.79

Q86XD5

(UniProtKB/Swiss-Prot/P) Details

Protein FAM131B

P16260

Interaction Score

0.738

Q9BV94

(UniProtKB/Swiss-Prot/P) Details

ER degradation-enhancing alpha-mannosidase-like protein 2

P16260

Interaction Score

0.64

F6SYF8

(UniProtKB/TrEmbl/P) Details

Dickkopf-related protein 3

P16260

Interaction Score

0.637

Q7Z345

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp686L0872

P16260

Interaction Score

0.56

O94871

(UniProtKB/TrEmbl/P) Details

KIAA0773 protein

P16260

Interaction Score

0.56

Q6PK61

(UniProtKB/TrEmbl/P) Details

Neuregulin 1

P16260

Interaction Score

Q9H496

(UniProtKB/Swiss-Prot/P) Details

Torsin-1A-interacting protein 2, isoform IFRG15

P16260

Interaction Score

Q7RTW3

(UniProtKB/TrEmbl/P) Details

Neuregulin 1 isoform HRG-beta2

P16260

Interaction Score

F6RJN6

(UniProtKB/TrEmbl/P) Details

Pro-neuregulin-1, membrane-bound isoform

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P16260

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P16260

P01903

HLA class II histocompatibility antigen, DR alpha chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260

P20036

HLA class II histocompatibility antigen, DP alpha 1 chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260

P40259

B-cell antigen receptor complex-associated protein beta chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260

Q96EV8

Dysbindin

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260

P26012

Integrin beta-8

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260

P08247

Synaptophysin

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260

Q02297

Pro-neuregulin-1, membrane-bound isoform

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260

Q9BRK5

45 kDa calcium-binding protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260

Q9UBP4

Dickkopf-related protein 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260

Q96KN2

Beta-Ala-His dipeptidase

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260

Q96CS3

FAS-associated factor 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260

P20851

C4b-binding protein beta chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P16260