P78385

Keratin, type II cuticular Hb3 // UniProt Profile

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Species	H. sapiens
Number of Interactions	38 / 42
Average Interaction Score	0.78

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.991	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.991	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.991	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.991	Unknown: traceable author statement	GO	PubMed
Cytosol	Keratin filament (GO:0045095)	0.991	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.3	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

P78385

Interaction Score

0.999

P42566

(UniProtKB/Swiss-Prot/P) Details

Epidermal growth factor receptor substrate 15

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Coated pit (GO:0005905)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Aggresome (GO:0016235)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cilium membrane (GO:0060170)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.999	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane (GO:0016020)	0.999	Unknown: HDA	GO	PubMed
Membrane	AP-2 adaptor complex (GO:0030122)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Basal plasma membrane (GO:0009925)	0.999	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P78385

Interaction Score

0.998

P62993

(UniProtKB/Swiss-Prot/P) Details

Growth factor receptor-bound protein 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Signalosome (GO:0008180)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.86	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Unknown: traceable author statement	GO	PubMed
Membrane	Extrinsic to internal side of plasma membrane (GO:0031234)	0.971	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Grb2-EGFR complex (GO:0070436)	0.971	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed
Cytosol	Vesicle membrane (GO:0012506)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	0.971	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P78385

Interaction Score

0.998

P08727

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 19

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Costamere (GO:0043034)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Z disc (GO:0030018)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intermediate filament (GO:0005882)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Terminal web (GO:1990357)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell periphery (GO:0071944)	0.986	Experimental: inferred from direct assay	GO	PubMed
Membrane	Dystrophin-associated glycoprotein complex (GO:0016010)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.986	Experimental: inferred from direct assay	GO	PubMed
Membrane	Sarcolemma (GO:0042383)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Apicolateral plasma membrane (GO:0016327)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P78385

Interaction Score

0.998

P09211

(UniProtKB/Swiss-Prot/P) Details

Glutathione S-transferase P

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	TRAF2-GSTP1 complex (GO:0097057)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular (GO:0005622)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.988	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.988	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.3	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.51	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.51	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Vesicle (GO:0031982)	1	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P78385

Interaction Score

0.997

P55040

(UniProtKB/Swiss-Prot/P) Details

GTP-binding protein GEM

P78385

Interaction Score

0.997

Q15323

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha1

P78385

Interaction Score

0.997

O76011

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha4

P78385

Interaction Score

0.996

Q14525

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha3-II

P78385

Interaction Score

0.991

P08779

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 16

P78385

Interaction Score

0.99

P19012

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 15

P78385

Interaction Score

0.99

P42229

(UniProtKB/Swiss-Prot/P) Details

Signal transducer and activator of transcription 5A

P78385

Interaction Score

0.987

Q92764

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha5

P78385

Interaction Score

0.985

O76014

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha7

P78385

Interaction Score

0.985

O76015

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha8

P78385

Interaction Score

0.979

P09651

(UniProtKB/Swiss-Prot/P) Details

Heterogeneous nuclear ribonucleoprotein A1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Ribonucleoprotein complex (GO:0030529)	0.972	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Spliceosomal complex (GO:0005681)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Catalytic step 2 spliceosome (GO:0071013)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.972	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P78385

Interaction Score

0.971

Q7Z3Z0

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 25

P78385

Interaction Score

0.965

Q8WTX9

(UniProtKB/Swiss-Prot/P) Details

Probable palmitoyltransferase ZDHHC1

P78385

Interaction Score

0.961

Q7Z3Y8

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 27

P78385

Interaction Score

0.959

Q6A163

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 39

P78385

Interaction Score

0.947

Q6A162

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 40

P78385

Interaction Score

0.947

A8MQ03

(UniProtKB/Swiss-Prot/P) Details

Cysteine-rich tail protein 1

P78385

Interaction Score

0.916

Q8IUC1

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 11-1

P78385

Interaction Score

0.823

Q12837

(UniProtKB/Swiss-Prot/P) Details

POU domain, class 4, transcription factor 2

P78385

Interaction Score

0.807

Q7Z3S9

(UniProtKB/Swiss-Prot/P) Details

Notch homolog 2 N-terminal-like protein

P78385

Interaction Score

0.793

O43482

(UniProtKB/Swiss-Prot/P) Details

Protein Mis18-beta

P78385

Interaction Score

0.72

Q6NUJ2

(UniProtKB/Swiss-Prot/P) Details

Uncharacterized protein C11orf87

P78385

Interaction Score

0.694

Q5BKY6

(UniProtKB/Swiss-Prot/P) Details

Putative uncharacterized protein DKFZp434K191

P78385

Interaction Score

0.609

P60409

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 10-7

P78385

Interaction Score

0.609

Q9BYR6

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 3-3

P78385

Interaction Score

0.609

P60410

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 10-8

P78385

Interaction Score

0.609

Q3LI66

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 6-2

P78385

Interaction Score

0.506

Q3SY46

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 13-3

P78385

Interaction Score

0.506

P60411

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 10-9

P78385

Interaction Score

0.506

P60369

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 10-3

P78385

Interaction Score

0.297

P78337

(UniProtKB/Swiss-Prot/P) Details

Pituitary homeobox 1

P78385

Interaction Score

Q49AR9

(UniProtKB/TrEmbl/P) Details

ANKS1A protein

P78385

Interaction Score

Q6FHY5

(UniProtKB/TrEmbl/P) Details

MEOX2 protein

P78385

Interaction Score

P49639

(UniProtKB/Swiss-Prot/P) Details

Homeobox protein Hox-A1

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P78385

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P78385

P42566

Epidermal growth factor receptor substrate 15

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385

P62993

Growth factor receptor-bound protein 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385

P08727

Keratin, type I cytoskeletal 19

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385

P09211

Glutathione S-transferase P

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385

P55040

GTP-binding protein GEM

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385

Q15323

Keratin, type I cuticular Ha1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385

O76011

Keratin, type I cuticular Ha4

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385

Q14525

Keratin, type I cuticular Ha3-II

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385

P08779

Keratin, type I cytoskeletal 16

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385

P19012

Keratin, type I cytoskeletal 15

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385

P42229

Signal transducer and activator of transcription 5A

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385

Q92764

Keratin, type I cuticular Ha5

Localizations:

Interaction Source Database:

Interaction Source Publication:

P78385