Q14416

Metabotropic glutamate receptor 2    //   UniProt Profile 

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Species

 H. sapiens

Number of Interactions

 28 / 30

Average Interaction Score

 0.863

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular (GO:0005622) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Membrane Dendrite (GO:0030425) 0.993 Unknown: inferred from electronic annotation GO PubMed 
Membrane Axon (GO:0030424) 0.993 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.993 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.993 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 0.993 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.993 Unknown: traceable author statement GO PubMed 
Membrane Cell junction (GO:0030054) 0.993 Unknown: inferred from electronic annotation GO PubMed 
Membrane Presynaptic membrane (GO:0042734) 0.993 Unknown: inferred from electronic annotation GO PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

Q14416

Interaction Score
0.999

O00560

(UniProtKB/Swiss-Prot/P) Details

Syntenin-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Unknown: non-traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nuclear membrane (GO:0031965) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.931 Experimental: experimental eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.931 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Melanosome (GO:0042470) 0.931 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Azurophil granule lumen (GO:0035578) 0.931 Unknown: traceable author statement GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Unknown: non-traceable author statement GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: experimental Organelle PubMed 
Extracellular Extracellular region (GO:0005576) 0.931 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.931 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular space (GO:0005615) 0.931 Unknown: HDA GO PubMed 
Extracellular Blood microparticle (GO:0072562) 0.931 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental eSLDB PubMed 
Membrane Membrane (GO:0016020) 1 Unknown: non-traceable author statement GO PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental MatrixDB PubMed 
Membrane Membrane raft (GO:0045121) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: experimental Organelle PubMed 
Membrane Interleukin-5 receptor complex (GO:0005895) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 
Membrane Adherens junction (GO:0005912) 1 Unknown: non-traceable author statement GO PubMed 
Membrane Focal adhesion (GO:0005925) 1 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.999

P27105

(UniProtKB/Swiss-Prot/P) Details

Erythrocyte band 7 integral membrane protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: experimental Human Proteinpedia PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.98 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.98 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Melanosome (GO:0042470) 0.98 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Tertiary granule membrane (GO:0070821) 0.98 Unknown: traceable author statement GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoskeleton (GO:0005856) 1 Experimental: experimental Organelle PubMed 
Extracellular Extracellular region (GO:0005576) 0.902 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular space (GO:0005615) 0.902 Unknown: HDA GO PubMed 
Extracellular Blood microparticle (GO:0072562) 0.902 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 1 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Predicted: SVM decision tree eSLDB PubMed 
Membrane Membrane raft (GO:0045121) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Integral to plasma membrane (GO:0005887) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Vesicle (GO:0031982) 1 Unknown: HDA GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.998

P28223

(UniProtKB/Swiss-Prot/P) Details

5-hydroxytryptamine receptor 2A

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Neuronal cell body (GO:0043025) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytosol (GO:0005829) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Membrane Dendritic shaft (GO:0043198) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell body fiber (GO:0070852) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Axon (GO:0030424) 1 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Caveola (GO:0005901) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Integral to plasma membrane (GO:0005887) 1 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

DIP

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.998

P50148

(UniProtKB/Swiss-Prot/P) Details

Guanine nucleotide-binding protein G(q) subunit alpha

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cell body (GO:0044297) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: pTarget method LOCATE PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nuclear speck (GO:0016607) 0.86 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Lysosomal membrane (GO:0005765) 0.999 Unknown: HDA GO PubMed 
Membrane Dendrite (GO:0030425) 0.998 Unknown: inferred from electronic annotation GO PubMed 
Membrane Photoreceptor outer segment (GO:0001750) 0.998 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.998 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.998 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Heterotrimeric G-protein complex (GO:0005834) 0.998 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.999 Unknown: HDA GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.998

O95484

(UniProtKB/Swiss-Prot/P) Details

Claudin-9

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.998 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.998 Experimental: inferred from direct assay GO PubMed 
Membrane Cell junction (GO:0030054) 0.998 Experimental: inferred from direct assay GO PubMed 
Membrane Cell junction (GO:0030054) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Tight junction (GO:0005923) 0.998 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.997

Q9Y3R0

(UniProtKB/Swiss-Prot/P) Details

Glutamate receptor-interacting protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.937 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.937 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.937 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: pTarget method LOCATE PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.853 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.853 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Recycling endosome (GO:0055037) 0.853 Unknown: inferred from electronic annotation GO PubMed 
Membrane Neuron projection (GO:0043005) 0.994 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Dendrite (GO:0030425) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane raft (GO:0045121) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.994 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.994 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Cell junction (GO:0030054) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Membrane Postsynaptic membrane (GO:0045211) 0.994 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.996

P57739

(UniProtKB/Swiss-Prot/P) Details

Claudin-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.8 Experimental: experimental eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.994 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell junction (GO:0030054) 0.994 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Tight junction (GO:0005923) 0.994 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.996

Q9H2H9

(UniProtKB/Swiss-Prot/P) Details

Sodium-coupled neutral amino acid transporter 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.996 Predicted: SVM decision tree eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.996 Unknown: non-traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.996 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.996

Q13520

(UniProtKB/Swiss-Prot/P) Details

Aquaporin-6

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Cytoplasmic vesicle membrane (GO:0030659) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.996 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.996 Unknown: traceable author statement GO PubMed 
Membrane Apical plasma membrane (GO:0016324) 0.996 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.993

Q7Z6J2

(UniProtKB/Swiss-Prot/P) Details

General receptor for phosphoinositides 1-associated scaffold protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.992 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.992 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 0.992 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nuclear body (GO:0016604) 0.988 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Postsynaptic density (GO:0014069) 0.979 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.979 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.979 Predicted: inferred from biological aspect of ancestor GO PubMed 
Membrane Cell junction (GO:0030054) 0.979 Unknown: inferred from electronic annotation GO PubMed 
Membrane Postsynaptic membrane (GO:0045211) 0.979 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.993

Q8IWU4

(UniProtKB/Swiss-Prot/P) Details

Zinc transporter 8

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: pTarget method LOCATE PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Secretory granule (GO:0030141) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Secretory granule membrane (GO:0030667) 0.999 Unknown: traceable author statement GO PubMed 
Secretory-pathway Transport vesicle membrane (GO:0030658) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.987 Predicted: SVM decision tree eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.987 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.987 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.987 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.991

O14924

(UniProtKB/Swiss-Prot/P) Details

Regulator of G-protein signaling 12

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.94 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytosol (GO:0005829) 0.94 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleolus (GO:0005730) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleolus (GO:0005730) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear matrix (GO:0016363) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Chromosome (GO:0005694) 1 Experimental: experimental Organelle PubMed 
Nucleus Condensed nuclear chromosome (GO:0000794) 1 Unknown: traceable author statement GO PubMed 
Membrane Dendrite (GO:0030425) 0.994 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.994 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.994 Predicted: inferred from biological aspect of ancestor GO PubMed 
Membrane Cell junction (GO:0030054) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Membrane Synapse (GO:0045202) 0.994 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.982

Q8N4V1

(UniProtKB/Swiss-Prot/P) Details

Membrane magnesium transporter 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Secretory-pathway ER membrane protein complex (GO:0072546) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Early endosome (GO:0005769) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Early endosome membrane (GO:0031901) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.958 Unknown: HDA GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.958 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.958 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.968

P00387

(UniProtKB/Swiss-Prot/P) Details

NADH-cytochrome b5 reductase 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Lipid particle (GO:0005811) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Hemoglobin complex (GO:0005833) 0.999 Unknown: traceable author statement GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.51 Unknown: HDA GO PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 0.51 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: experimental Human Proteinpedia PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.998 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.998 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Azurophil granule lumen (GO:0035578) 0.998 Unknown: traceable author statement GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.86 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.86 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.965

Q8N3G9

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 130

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 1 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Experimental: experimental Human Proteinpedia PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: experimental Human Proteinpedia PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 1 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.961

Q13323

(UniProtKB/Swiss-Prot/P) Details

Bcl-2-interacting killer

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Endomembrane system (GO:0012505) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.86 Experimental: experimental eSLDB PubMed 
Mitochondrion Mitochondrial membrane (GO:0031966) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: experimental eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.86 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.86 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.961

Q13113

(UniProtKB/Swiss-Prot/P) Details

PDZK1-interacting protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.86 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear speck (GO:0016607) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.86 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.86 Unknown: HDA GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.951

P30679

(UniProtKB/Swiss-Prot/P) Details

Guanine nucleotide-binding protein subunit alpha-15

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.958 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.958 Experimental: experimental Organelle PubMed 
Membrane Heterotrimeric G-protein complex (GO:0005834) 0.958 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.948

Q9UMX0

(UniProtKB/Swiss-Prot/P) Details

Ubiquilin-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Aggresome (GO:0016235) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Proteasome complex (GO:0000502) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Unknown: non-traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.86 Experimental: inferred from direct assay GO PubMed 
Cytosol Autophagic vacuole (GO:0005776) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.947

Q8WV48

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 107

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.941

Q9NWD8

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 248

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.79 Predicted: SVM decision tree eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.79 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.939

Q58DX5

(UniProtKB/Swiss-Prot/P) Details

Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Peroxisome (GO:0005777) 0.7 Predicted: pTarget method LOCATE PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.79 Predicted: SVM decision tree eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.79 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.926

Q8WUV1

(UniProtKB/TrEmbl/P) Details

Tetraspanin

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.8 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.748

P02545

(UniProtKB/Swiss-Prot/P) Details

Prelamin-A/C

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Endomembrane system (GO:0012505) 0.998 Experimental: experimental Organelle PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Unknown: HDA GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Lamin filament (GO:0005638) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 1 Unknown: HDA GO PubMed 
Nucleus Nuclear envelope (GO:0005635) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear speck (GO:0016607) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.998 Experimental: experimental Organelle PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.8 Experimental: experimental MatrixDB PubMed 
Cytosol Organelle inner membrane (GO:0019866) 0.998 Experimental: experimental Organelle PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.282

Q9NR31

(UniProtKB/Swiss-Prot/P) Details

GTP-binding protein SAR1a

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.94 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 0.94 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.998 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.998 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway COPII vesicle coat (GO:0030127) 0.998 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.24

G5EA09

(UniProtKB/TrEmbl/P) Details

Syndecan binding protein (Syntenin), isoform CRA_a

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.24

B4DHN5

(UniProtKB/TrEmbl/P) Details

cDNA FLJ55055, moderately similar to Syntenin-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q14416

Interaction Score
0.21

Q5TCI8

(UniProtKB/TrEmbl/P) Details

Prelamin-A/C

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015