Q5T011

KICSTOR complex protein SZT2 // UniProt Profile

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Species	H. sapiens
Number of Interactions	33 / 44
Average Interaction Score	0.9

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
N/A	Iml1 complex (GO:1990130)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.94	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Peroxisome (GO:0005777)	0.998	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.7	Predicted: SVM decision tree	eSLDB	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q5T011

Interaction Score

Q9Y664

(UniProtKB/Swiss-Prot/P) Details

KICSTOR complex protein kaptin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Stereocilium (GO:0032420)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Filamentous actin (GO:0031941)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	0.96	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q5T011

Interaction Score

Q9NXC5

(UniProtKB/Swiss-Prot/P) Details

GATOR complex protein MIOS

Q5T011

Interaction Score

P55735

(UniProtKB/Swiss-Prot/P) Details

Protein SEC13 homolog

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nuclear envelope (GO:0005635)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nup107-160 complex (GO:0031080)	1	Unknown: non-traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.931	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.931	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	COPII vesicle coat (GO:0030127)	0.931	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Kinetochore (GO:0000776)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q5T011

Interaction Score

P34897

(UniProtKB/Swiss-Prot/P) Details

Serine hydroxymethyltransferase, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial matrix (GO:0005759)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial nucleoid (GO:0042645)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial intermembrane space (GO:0005758)	1	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	BRISC complex (GO:0070552)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.998	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q5T011

Interaction Score

P54725

(UniProtKB/Swiss-Prot/P) Details

UV excision repair protein RAD23 homolog A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Proteasome complex (GO:0000502)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q5T011

Interaction Score

P13473

(UniProtKB/Swiss-Prot/P) Details

Lysosome-associated membrane glycoprotein 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	1	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.999	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Late endosome membrane (GO:0031902)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal lumen (GO:0043202)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Platelet dense granule membrane (GO:0031088)	0.999	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.998	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.998	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Membrane raft (GO:0045121)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q5T011

Interaction Score

P58004

(UniProtKB/Swiss-Prot/P) Details

Sestrin-2

Q5T011

Interaction Score

Q9H7D0

(UniProtKB/Swiss-Prot/P) Details

Dedicator of cytokinesis protein 5

Q5T011

Interaction Score

P11279

(UniProtKB/Swiss-Prot/P) Details

Lysosome-associated membrane glycoprotein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Neuronal cell body (GO:0043025)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.986	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Multivesicular body (GO:0005771)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.986	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytolytic granule (GO:0044194)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Melanosome (GO:0042470)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Alveolar lamellar body (GO:0097208)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Integral to synaptic vesicle membrane (GO:0030285)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendrite (GO:0030425)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.999	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Membrane	Sarcolemma (GO:0042383)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	External side of plasma membrane (GO:0009897)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q5T011

Interaction Score

O75140

(UniProtKB/Swiss-Prot/P) Details

GATOR complex protein DEPDC5

Q5T011

Interaction Score

0.999

Q6PJI9

(UniProtKB/Swiss-Prot/P) Details

GATOR complex protein WDR59

Q5T011

Interaction Score

0.999

Q96S15

(UniProtKB/Swiss-Prot/P) Details

GATOR complex protein WDR24

Q5T011

Interaction Score

0.998

Q969R8

(UniProtKB/Swiss-Prot/P) Details

KICSTOR complex protein ITFG2

Q5T011

Interaction Score

0.998

Q8WTW4

(UniProtKB/Swiss-Prot/P) Details

GATOR complex protein NPRL2

Q5T011

Interaction Score

0.997

P15884

(UniProtKB/Swiss-Prot/P) Details

Transcription factor 4

Q5T011

Interaction Score

0.997

Q96EE3

(UniProtKB/Swiss-Prot/P) Details

Nucleoporin SEH1

Q5T011

Interaction Score

0.996

Q96AP4

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin carboxyl-terminal hydrolase ZUFSP

Q5T011

Interaction Score

0.995

Q12980

(UniProtKB/Swiss-Prot/P) Details

GATOR complex protein NPRL3

Q5T011

Interaction Score

0.994

Q04864

(UniProtKB/Swiss-Prot/P) Details

Proto-oncogene c-Rel

Q5T011

Interaction Score

0.979

Q9BXJ5

(UniProtKB/Swiss-Prot/P) Details

Complement C1q tumor necrosis factor-related protein 2

Q5T011

Interaction Score

0.979

Q1RMZ1

(UniProtKB/Swiss-Prot/P) Details

S-adenosylmethionine sensor upstream of mTORC1

Q5T011

Interaction Score

0.95

A0A1B0GW91

(UniProtKB/TrEmbl/P) Details

Transcription factor 4

Q5T011

Interaction Score

0.95

H3BTP3

(UniProtKB/TrEmbl/P) Details

Transcription factor 4

Q5T011

Interaction Score

0.95

H3BPJ7

(UniProtKB/TrEmbl/P) Details

Transcription factor 4

Q5T011

Interaction Score

0.95

E9PH57

(UniProtKB/TrEmbl/P) Details

Transcription factor 4, isoform CRA_e

Q5T011

Interaction Score

0.95

A0A1B0GVR6

(UniProtKB/TrEmbl/P) Details

Transcription factor 4

Q5T011

Interaction Score

0.95

A0A1B0GWD5

(UniProtKB/TrEmbl/P) Details

Transcription factor 4

Q5T011

Interaction Score

0.923

O43186

(UniProtKB/Swiss-Prot/P) Details

Cone-rod homeobox protein

Q5T011

Interaction Score

0.798

B9A015

(UniProtKB/TrEmbl/P) Details

Dedicator of cytokinesis protein 5

Q5T011

Interaction Score

0.698

Q5BJF5

(UniProtKB/TrEmbl/P) Details

Serine hydroxymethyltransferase

Q5T011

Interaction Score

0.658

Q68DL4

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp781J211

Q5T011

Interaction Score

Q5HYG8

(UniProtKB/TrEmbl/P) Details

Serine hydroxymethyltransferase

Q5T011

Interaction Score

A0A2R8Y6H3

(UniProtKB/TrEmbl/P) Details

GATOR complex protein DEPDC5

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Q5T011

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q5T011

Q9Y664

KICSTOR complex protein kaptin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011

Q9NXC5

GATOR complex protein MIOS

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011

P55735

Protein SEC13 homolog

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011

P34897

Serine hydroxymethyltransferase, mitochondrial

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011

P54725

UV excision repair protein RAD23 homolog A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011

P13473

Lysosome-associated membrane glycoprotein 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011

P58004

Sestrin-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011

Q9H7D0

Dedicator of cytokinesis protein 5

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011

P11279

Lysosome-associated membrane glycoprotein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011

O75140

GATOR complex protein DEPDC5

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011

Q6PJI9

GATOR complex protein WDR59

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011

Q96S15

GATOR complex protein WDR24

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q5T011