Q9BU23

Lipase maturation factor 2 // UniProt Profile

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Species	H. sapiens
Number of Interactions	38 / 45
Average Interaction Score	0.876

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.7	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.853	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.853	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.853	Unknown: inferred from electronic annotation	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q9BU23

Interaction Score

0.998

P05067

(UniProtKB/Swiss-Prot/P) Details

Amyloid-beta A4 protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Coated pit (GO:0005905)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Apical part of cell (GO:0045177)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	eSLDB	PubMed
Nucleus	Nuclear envelope lumen (GO:0005641)	0.96	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Rough endoplasmic reticulum (GO:0005791)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Smooth endoplasmic reticulum (GO:0005790)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome lumen (GO:0031904)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle (GO:0030134)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Spindle midzone (GO:0051233)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Astrocyte projection (GO:0097449)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendritic shaft (GO:0043198)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Axon (GO:0030424)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Main axon (GO:0044304)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Ciliary rootlet (GO:0035253)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.98	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.98	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.98	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.98	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Membrane raft (GO:0045121)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Vesicle (GO:0031982)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Synapse (GO:0045202)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Presynaptic active zone (GO:0048786)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9BU23

Interaction Score

0.996

Q9BQG1

(UniProtKB/Swiss-Prot/P) Details

Synaptotagmin-3

Q9BU23

Interaction Score

0.994

P27824

(UniProtKB/Swiss-Prot/P) Details

Calnexin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	0.966	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.657	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Ribosome (GO:0005840)	0.657	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Rough endoplasmic reticulum (GO:0005791)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Smooth endoplasmic reticulum (GO:0005790)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum quality control compartment (GO:0044322)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Melanosome (GO:0042470)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendrite cytoplasm (GO:0032839)	0.966	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	0.966	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axon (GO:0030424)	0.966	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.96	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.966	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.966	Experimental: experimental	eSLDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.657	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q9BU23

Interaction Score

0.993

P30519

(UniProtKB/Swiss-Prot/P) Details

Heme oxygenase 2

Q9BU23

Interaction Score

0.992

Q96GX1

(UniProtKB/Swiss-Prot/P) Details

Tectonic-2

Q9BU23

Interaction Score

0.991

Q6UWR7

(UniProtKB/Swiss-Prot/P) Details

Ectonucleotide pyrophosphatase/phosphodiesterase family member 6

Q9BU23

Interaction Score

0.987

Q6NUS6

(UniProtKB/Swiss-Prot/P) Details

Tectonic-3

Q9BU23

Interaction Score

0.985

P46098

(UniProtKB/Swiss-Prot/P) Details

5-hydroxytryptamine receptor 3A

Q9BU23

Interaction Score

0.982

O95498

(UniProtKB/Swiss-Prot/P) Details

Vascular non-inflammatory molecule 2

Q9BU23

Interaction Score

0.98

P08833

(UniProtKB/Swiss-Prot/P) Details

Insulin-like growth factor-binding protein 1

Q9BU23

Interaction Score

0.979

O00322

(UniProtKB/Swiss-Prot/P) Details

Uroplakin-1a

Q9BU23

Interaction Score

0.978

Q6PIU2

(UniProtKB/Swiss-Prot/P) Details

Neutral cholesterol ester hydrolase 1

Q9BU23

Interaction Score

0.977

Q15323

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha1

Q9BU23

Interaction Score

0.975

O75326

(UniProtKB/Swiss-Prot/P) Details

Semaphorin-7A

Q9BU23

Interaction Score

0.975

Q9UNA3

(UniProtKB/Swiss-Prot/P) Details

Alpha-1,4-N-acetylglucosaminyltransferase

Q9BU23

Interaction Score

0.965

Q53F39

(UniProtKB/Swiss-Prot/P) Details

Metallophosphoesterase 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Endoplasmic reticulum exit site (GO:0070971)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Cis-Golgi network (GO:0005801)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9BU23

Interaction Score

0.962

O15496

(UniProtKB/Swiss-Prot/P) Details

Group 10 secretory phospholipase A2

Q9BU23

Interaction Score

0.958

P42263

(UniProtKB/Swiss-Prot/P) Details

Glutamate receptor 3

Q9BU23

Interaction Score

0.958

Q13137

(UniProtKB/Swiss-Prot/P) Details

Calcium-binding and coiled-coil domain-containing protein 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Autophagic vacuole (GO:0005776)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Autophagic vacuole membrane (GO:0000421)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q9BU23

Interaction Score

0.953

Q8NA58

(UniProtKB/Swiss-Prot/P) Details

Poly(A)-specific ribonuclease PNLDC1

Q9BU23

Interaction Score

0.947

P78334

(UniProtKB/Swiss-Prot/P) Details

Gamma-aminobutyric acid receptor subunit epsilon

Q9BU23

Interaction Score

0.944

Q9UN42

(UniProtKB/Swiss-Prot/P) Details

Protein ATP1B4

Q9BU23

Interaction Score

0.943

Q401N2

(UniProtKB/Swiss-Prot/P) Details

Zinc-activated ligand-gated ion channel

Q9BU23

Interaction Score

0.943

Q8WXA8

(UniProtKB/Swiss-Prot/P) Details

5-hydroxytryptamine receptor 3C

Q9BU23

Interaction Score

0.936

P53355

(UniProtKB/Swiss-Prot/P) Details

Death-associated protein kinase 1

Q9BU23

Interaction Score

0.936

A0A0A0MRG2

(UniProtKB/TrEmbl/P) Details

Amyloid-beta A4 protein

Q9BU23

Interaction Score

0.842

E9PG40

(UniProtKB/TrEmbl/P) Details

Amyloid-beta A4 protein

Q9BU23

Interaction Score

0.84

Q9NRD1

(UniProtKB/Swiss-Prot/P) Details

F-box only protein 6

Q9BU23

Interaction Score

0.823

A0A0A0MR93

(UniProtKB/TrEmbl/P) Details

Metallophosphoesterase 1

Q9BU23

Interaction Score

0.795

Q5XKG2

(UniProtKB/TrEmbl/P) Details

Glutamate receptor 3

Q9BU23

Interaction Score

0.794

Q8IWL3

(UniProtKB/Swiss-Prot/P) Details

Iron-sulfur cluster co-chaperone protein HscB, mitochondrial

Q9BU23

Interaction Score

0.768

A0A087WT44

(UniProtKB/TrEmbl/P) Details

Heme oxygenase 2

Q9BU23

Interaction Score

0.765

Q6A162

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 40

Q9BU23

Interaction Score

0.682

Q17R51

(UniProtKB/TrEmbl/P) Details

GRIA3 protein

Q9BU23

Interaction Score

0.56

A0A0A0MTJ9

(UniProtKB/TrEmbl/P) Details

Neutral cholesterol ester hydrolase 1

Q9BU23

Interaction Score

0.56

A0A0R4J2G3

(UniProtKB/TrEmbl/P) Details

Arylacetamide deacetylase-like 1

Q9BU23

Interaction Score

0.408

P60369

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 10-3

Q9BU23

Interaction Score

0.24

F5GYX3

(UniProtKB/TrEmbl/P) Details

Semaphorin-7A

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Q9BU23

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q9BU23

P05067

Amyloid-beta A4 protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23

Q9BQG1

Synaptotagmin-3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23

P27824

Calnexin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23

P30519

Heme oxygenase 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23

Q96GX1

Tectonic-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23

Q6UWR7

Ectonucleotide pyrophosphatase/phosphodiesterase family member 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23

Q6NUS6

Tectonic-3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23

P46098

5-hydroxytryptamine receptor 3A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23

O95498

Vascular non-inflammatory molecule 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23

P08833

Insulin-like growth factor-binding protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23

O00322

Uroplakin-1a

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23

Q6PIU2

Neutral cholesterol ester hydrolase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9BU23