P59665

Neutrophil defensin 1 // UniProt Profile

Custom Settings: Use these controls to filter the data displayed on this page. The parameters apply to both the query protein and its interactors. Details

The (filtered) results are available for download, see the help for details. Download The Results

Species	H. sapiens
Number of Interactions	128 / 158
Average Interaction Score	0.829

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.902	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	0.902	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Azurophil granule lumen (GO:0035578)	0.902	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.997	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.997	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.997	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.997	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.997	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

First-Neighbour Network Visualization

Toggle Display

This first-neighbour network contains 129 nodes, therefore its visualization may slow down your browser.
Click on 'Toggle Display' to start network visualization.

Interactions

All Details

P59665

Interaction Score

P01137

(UniProtKB/Swiss-Prot/P) Details

Transforming growth factor beta-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.853	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.996	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.98	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.98	Unknown: unspecified method	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	0.853	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.853	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.98	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Microvillus (GO:0005902)	0.996	Experimental: inferred from direct assay	GO	PubMed
Membrane	Axon (GO:0030424)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.999	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.999	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.996	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.996	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

Q9Y4K0

(UniProtKB/Swiss-Prot/P) Details

Lysyl oxidase homolog 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.96	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.994	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.994	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.994	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromatin (GO:0000785)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Basement membrane (GO:0005604)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

P23142

(UniProtKB/Swiss-Prot/P) Details

Fibulin-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.94	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	1	Unknown: HDA	GO	PubMed
Extracellular	Fibrinogen complex (GO:0005577)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Elastic fiber (GO:0071953)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Basement membrane (GO:0005604)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

P18065

(UniProtKB/Swiss-Prot/P) Details

Insulin-like growth factor-binding protein 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.958	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.958	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.999	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

P41221

(UniProtKB/Swiss-Prot/P) Details

Protein Wnt-5a

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.95	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.95	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	0.95	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.95	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin coated vesicle membrane (GO:0030665)	0.95	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.95	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.998	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.998	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.998	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.998	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.902	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.902	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

Q03167

(UniProtKB/Swiss-Prot/P) Details

Transforming growth factor beta receptor type 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.8	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.657	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.657	Unknown: unspecified method	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.999	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Inhibin-betaglycan-ActRII complex (GO:0034673)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.657	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

Q9NZ08

(UniProtKB/Swiss-Prot/P) Details

Endoplasmic reticulum aminopeptidase 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.979	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.98	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.98	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.98	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.979	Unknown: non-traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.979	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.979	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.979	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.992	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.994	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.994	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.994	Unknown: non-traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.994	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.994	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.98	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

Q16787

(UniProtKB/Swiss-Prot/P) Details

Laminin subunit alpha-3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.988	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.988	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.994	Experimental: experimental	MatrixDB	PubMed
Extracellular	Laminin-5 complex (GO:0005610)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Basement membrane (GO:0005604)	0.994	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.96	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.96	Experimental: experimental	Organelle	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

O15230

(UniProtKB/Swiss-Prot/P) Details

Laminin subunit alpha-5

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Unknown: HDA	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Laminin-10 complex (GO:0043259)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Laminin-11 complex (GO:0043260)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Laminin-5 complex (GO:0005610)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Basement membrane (GO:0005604)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.902	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.86	Unknown: HDA	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Synaptic cleft (GO:0043083)	0.902	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

P07942

(UniProtKB/Swiss-Prot/P) Details

Laminin subunit beta-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.79	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.79	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Laminin-1 complex (GO:0005606)	1	Predicted: inferred from physical interaction	GO	PubMed
Extracellular	Laminin-10 complex (GO:0043259)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Laminin-2 complex (GO:0005607)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Laminin-8 complex (GO:0043257)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Basement membrane (GO:0005604)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.79	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

Q92626

(UniProtKB/Swiss-Prot/P) Details

Peroxidasin homolog

P59665

Interaction Score

P12109

(UniProtKB/Swiss-Prot/P) Details

Collagen alpha-1(VI) chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.902	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.7	Predicted: inferred from physical interaction	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.79	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.902	Unknown: HDA	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Experimental: experimental	MatrixDB	PubMed
Extracellular	Collagen type VI (GO:0005589)	0.999	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.902	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.902	Experimental: experimental	MatrixDB	PubMed
Membrane	Sarcolemma (GO:0042383)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.902	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

O94813

(UniProtKB/Swiss-Prot/P) Details

Slit homolog 2 protein

P59665

Interaction Score

Q14112

(UniProtKB/Swiss-Prot/P) Details

Nidogen-2

P59665

Interaction Score

O43405

(UniProtKB/Swiss-Prot/P) Details

Cochlin

P59665

Interaction Score

P35625

(UniProtKB/Swiss-Prot/P) Details

Metalloproteinase inhibitor 3

P59665

Interaction Score

Q6UVY6

(UniProtKB/Swiss-Prot/P) Details

DBH-like monooxygenase protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.995	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.94	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.995	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.995	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Secretory granule membrane (GO:0030667)	0.995	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.982	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.982	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.982	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.86	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

P08697

(UniProtKB/Swiss-Prot/P) Details

Alpha-2-antiplasmin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.51	Unknown: unspecified method	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.3	Unknown: unspecified method	The Human Protein Atlas	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.79	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Fibrinogen complex (GO:0005577)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.994	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.96	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.51	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.999

P39060

(UniProtKB/Swiss-Prot/P) Details

Collagen alpha-1(XVIII) chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.958	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.958	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.958	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.99	Unknown: HDA	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.99	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.99	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.99	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.99	Experimental: experimental	MatrixDB	PubMed
Extracellular	Collagen (GO:0005581)	0.99	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Basement membrane (GO:0005604)	0.99	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.999

P55268

(UniProtKB/Swiss-Prot/P) Details

Laminin subunit beta-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.3	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.998	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.998	Experimental: experimental	MatrixDB	PubMed
Extracellular	Laminin-11 complex (GO:0043260)	0.998	Unknown: traceable author statement	GO	PubMed
Extracellular	Laminin-3 complex (GO:0005608)	0.998	Predicted: inferred from physical interaction	GO	PubMed
Extracellular	Basement membrane (GO:0005604)	0.998	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.902	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.972	Unknown: HDA	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Synaptic cleft (GO:0043083)	0.902	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.999

Q9H4F8

(UniProtKB/Swiss-Prot/P) Details

SPARC-related modular calcium-binding protein 1

P59665

Interaction Score

0.999

P01130

(UniProtKB/Swiss-Prot/P) Details

Low-density lipoprotein receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Coated pit (GO:0005905)	0.997	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Apical part of cell (GO:0045177)	0.997	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Intracellular (GO:0005622)	0.997	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.996	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.996	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.996	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.996	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.997	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Endolysosome membrane (GO:0036020)	0.997	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.996	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Low-density lipoprotein particle (GO:0034362)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.999

P00750

(UniProtKB/Swiss-Prot/P) Details

Tissue-type plasminogen activator

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Apical part of cell (GO:0045177)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.994	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Secretory granule (GO:0030141)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.994	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.96	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.994	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.999

P59666

(UniProtKB/Swiss-Prot/P) Details

Neutrophil defensin 3

P59665

Interaction Score

0.999

Q29983

(UniProtKB/Swiss-Prot/P) Details

MHC class I polypeptide-related sequence A

P59665

Interaction Score

0.999

Q05707

(UniProtKB/Swiss-Prot/P) Details

Collagen alpha-1(XIV) chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.79	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.96	Experimental: experimental	Human Proteinpedia	PubMed
Extracellular	Extracellular region (GO:0005576)	0.99	Unknown: HDA	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.99	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.99	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.99	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.99	Experimental: experimental	MatrixDB	PubMed
Extracellular	Collagen (GO:0005581)	0.99	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Collagen type XIV (GO:0005596)	0.99	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.999

Q9BTN0

(UniProtKB/Swiss-Prot/P) Details

Leucine-rich repeat and fibronectin type-III domain-containing protein 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendrite (GO:0030425)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axon (GO:0030424)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.996	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.996	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.996	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.996	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.998	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Cell junction (GO:0030054)	0.998	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.999

Q5HYA8

(UniProtKB/Swiss-Prot/P) Details

Meckelin

P59665

Interaction Score

0.999

Q8IUL8

(UniProtKB/Swiss-Prot/P) Details

Cartilage intermediate layer protein 2

P59665

Interaction Score

0.998

P42702

(UniProtKB/Swiss-Prot/P) Details

Leukemia inhibitory factor receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.96	Experimental: experimental	eSLDB	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.999	Unknown: traceable author statement	GO	PubMed
Membrane	Receptor complex (GO:0043235)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.998

P06276

(UniProtKB/Swiss-Prot/P) Details

Cholinesterase

P59665

Interaction Score

0.998

P28799

(UniProtKB/Swiss-Prot/P) Details

Granulins

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Lysosome (GO:0005764)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Azurophil granule lumen (GO:0035578)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.937	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.937	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.937	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.972	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.998

P00533

(UniProtKB/Swiss-Prot/P) Details

Epidermal growth factor receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Endomembrane system (GO:0012505)	0.972	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.994	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.994	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Clathrin coated vesicle membrane (GO:0030665)	0.999	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.86	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane raft (GO:0045121)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	AP-2 adaptor complex (GO:0030122)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Shc-EGFR complex (GO:0070435)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed
Membrane	Synapse (GO:0045202)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.998

P13497

(UniProtKB/Swiss-Prot/P) Details

Bone morphogenetic protein 1

P59665

Interaction Score

0.998

P61916

(UniProtKB/Swiss-Prot/P) Details

NPC intracellular cholesterol transporter 2

P59665

Interaction Score

0.997

O60462

(UniProtKB/Swiss-Prot/P) Details

Neuropilin-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Semaphorin receptor complex (GO:0002116)	0.998	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Axon (GO:0030424)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.998	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.998	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Unknown: non-traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.997

P13639

(UniProtKB/Swiss-Prot/P) Details

Elongation factor 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Aggresome (GO:0016235)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Polysomal ribosome (GO:0042788)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: HDA	GO	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.3	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.972	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.972	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.972	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.997	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.997	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane raft (GO:0045121)	0.997	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.997	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.997	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Synapse (GO:0045202)	0.997	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.997

P02746

(UniProtKB/Swiss-Prot/P) Details

Complement C1q subcomponent subunit B

P59665

Interaction Score

0.994

Q9BSG0

(UniProtKB/Swiss-Prot/P) Details

Protease-associated domain-containing protein 1

P59665

Interaction Score

0.994

Q24JP5

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 132A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.969	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.969	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.969	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.969	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.969	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.91	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.91	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.994

P06756

(UniProtKB/Swiss-Prot/P) Details

Integrin alpha-V

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Phagocytic vesicle (GO:0045335)	0.3	Unknown: traceable author statement	GO	PubMed
Membrane	Ruffle membrane (GO:0032587)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Microvillus membrane (GO:0031528)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Lamellipodium membrane (GO:0031258)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Filopodium membrane (GO:0031527)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Alphav-beta3 integrin-IGF-1-IGF1R complex (GO:0035867)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Integrin complex (GO:0008305)	1	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.972	Unknown: HDA	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.992

Q6UWL2

(UniProtKB/Swiss-Prot/P) Details

Sushi domain-containing protein 1

P59665

Interaction Score

0.991

Q12841

(UniProtKB/Swiss-Prot/P) Details

Follistatin-related protein 1

P59665

Interaction Score

0.991

Q13683

(UniProtKB/Swiss-Prot/P) Details

Integrin alpha-7

P59665

Interaction Score

0.991

Q9NY47

(UniProtKB/Swiss-Prot/P) Details

Voltage-dependent calcium channel subunit alpha-2/delta-2

P59665

Interaction Score

0.99

O75054

(UniProtKB/Swiss-Prot/P) Details

Immunoglobulin superfamily member 3

P59665

Interaction Score

0.99

Q9BZ76

(UniProtKB/Swiss-Prot/P) Details

Contactin-associated protein-like 3

P59665

Interaction Score

0.99

O15031

(UniProtKB/Swiss-Prot/P) Details

Plexin-B2

P59665

Interaction Score

0.989

Q8IWU5

(UniProtKB/Swiss-Prot/P) Details

Extracellular sulfatase Sulf-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi stack (GO:0005795)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.3	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.998	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: experimental	Human Proteinpedia	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.989

Q9UM47

(UniProtKB/Swiss-Prot/P) Details

Neurogenic locus notch homolog protein 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.51	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.51	Unknown: traceable author statement	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.998	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: inferred from direct assay	GO	PubMed
Membrane	Receptor complex (GO:0043235)	0.998	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.988

Q9BZQ6

(UniProtKB/Swiss-Prot/P) Details

ER degradation-enhancing alpha-mannosidase-like protein 3

P59665

Interaction Score

0.986

O75976

(UniProtKB/Swiss-Prot/P) Details

Carboxypeptidase D

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.94	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Membrane (GO:0016020)	0.931	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.931	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.983

P15848

(UniProtKB/Swiss-Prot/P) Details

Arylsulfatase B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.94	Predicted: inferred from sequence or structural similarity	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Rough endoplasmic reticulum (GO:0005791)	0.952	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.952	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.952	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.952	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Lysosome (GO:0005764)	0.994	Experimental: experimental	eSLDB	PubMed
Cytosol	Lysosome (GO:0005764)	0.994	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.994	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Lysosome (GO:0005764)	0.994	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal lumen (GO:0043202)	0.994	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Azurophil granule lumen (GO:0035578)	0.952	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.3	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.94	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.994	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.98

P49641

(UniProtKB/Swiss-Prot/P) Details

Alpha-mannosidase 2x

P59665

Interaction Score

0.979

Q8WTV0

(UniProtKB/Swiss-Prot/P) Details

Scavenger receptor class B member 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.998	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.98	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.98	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.98	Unknown: HDA	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.3	Unknown: traceable author statement	GO	PubMed
Membrane	Microvillus membrane (GO:0031528)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Caveola (GO:0005901)	0.998	Unknown: traceable author statement	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.98	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.979

O95158

(UniProtKB/Swiss-Prot/P) Details

Neurexophilin-4

P59665

Interaction Score

0.978

Q8NBH6

(UniProtKB/TrEmbl/P) Details

Fibulin-1

P59665

Interaction Score

0.977

O60911

(UniProtKB/Swiss-Prot/P) Details

Cathepsin L2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Perikaryon (GO:0043204)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Apical part of cell (GO:0045177)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Fibrillar center (GO:0001650)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Lysosome (GO:0005764)	0.999	Experimental: experimental	eSLDB	PubMed
Cytosol	Lysosome (GO:0005764)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal lumen (GO:0043202)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Secretory granule (GO:0030141)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Microvillus (GO:0005902)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuron projection (GO:0043005)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.79	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.79	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Membrane (GO:0016020)	0.986	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.986	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	External side of plasma membrane (GO:0009897)	0.986	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.976

Q9UHD9

(UniProtKB/Swiss-Prot/P) Details

Ubiquilin-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Autophagic vacuole (GO:0005776)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.974

Q6UWY0

(UniProtKB/Swiss-Prot/P) Details

Arylsulfatase K

P59665

Interaction Score

0.973

Q6P1J6

(UniProtKB/Swiss-Prot/P) Details

Phospholipase B1, membrane-associated

P59665

Interaction Score

0.972

Q07157

(UniProtKB/Swiss-Prot/P) Details

Tight junction protein ZO-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Apical part of cell (GO:0045177)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Podosome (GO:0002102)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell projection (GO:0042995)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Apical junction complex (GO:0043296)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Cell-cell adherens junction (GO:0005913)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Gap junction (GO:0005921)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Tight junction (GO:0005923)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.97

Q96AE7

(UniProtKB/Swiss-Prot/P) Details

Tetratricopeptide repeat protein 17

P59665

Interaction Score

0.97

Q5VST6

(UniProtKB/Swiss-Prot/P) Details

Alpha/beta hydrolase domain-containing protein 17B

P59665

Interaction Score

0.97

P49841

(UniProtKB/Swiss-Prot/P) Details

Glycogen synthase kinase-3 beta

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.994	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Beta-catenin destruction complex (GO:0030877)	0.994	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.994	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Unknown: traceable author statement	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.994	Experimental: inferred from direct assay	GO	PubMed
Membrane	Dendrite (GO:0030425)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Axon (GO:0030424)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.982	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.969

Q08209

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Calcineurin complex (GO:0005955)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Z disc (GO:0030018)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	0.98	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Sarcolemma (GO:0042383)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Internal side of plasma membrane (GO:0009898)	0.98	Experimental: inferred from direct assay	GO	PubMed
Membrane	Slit diaphragm (GO:0036057)	0.98	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.967

Q9UHN6

(UniProtKB/Swiss-Prot/P) Details

Cell surface hyaluronidase

P59665

Interaction Score

0.966

P54289

(UniProtKB/Swiss-Prot/P) Details

Voltage-dependent calcium channel subunit alpha-2/delta-1

P59665

Interaction Score

0.966

O60243

(UniProtKB/Swiss-Prot/P) Details

Heparan-sulfate 6-O-sulfotransferase 1

P59665

Interaction Score

0.963

Q9Y561

(UniProtKB/Swiss-Prot/P) Details

Low-density lipoprotein receptor-related protein 12

P59665

Interaction Score

0.962

Q92545

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 131

P59665

Interaction Score

0.962

Q9UIW2

(UniProtKB/Swiss-Prot/P) Details

Plexin-A1

P59665

Interaction Score

0.96

P30532

(UniProtKB/Swiss-Prot/P) Details

Neuronal acetylcholine receptor subunit alpha-5

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Acetylcholine-gated channel complex (GO:0005892)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Cell junction (GO:0030054)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Postsynaptic membrane (GO:0045211)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.959

Q99538

(UniProtKB/Swiss-Prot/P) Details

Legumain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Apical part of cell (GO:0045177)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.79	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Lysosome (GO:0005764)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal lumen (GO:0043202)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Endolysosome lumen (GO:0036021)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P59665

Interaction Score

0.959

O75051

(UniProtKB/Swiss-Prot/P) Details

Plexin-A2

P59665

Interaction Score

0.956

P63098

(UniProtKB/Swiss-Prot/P) Details

Calcineurin subunit B type 1

P59665

Interaction Score

0.951

Q9UBX1

(UniProtKB/Swiss-Prot/P) Details

Cathepsin F

P59665

Interaction Score

0.949

Q15818

(UniProtKB/Swiss-Prot/P) Details

Neuronal pentraxin-1

P59665

Interaction Score

0.927

E9PFD7

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

P59665

Interaction Score

0.927

Q504U8

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

P59665

Interaction Score

0.927

A0A024R316

(UniProtKB/TrEmbl/P) Details

Protein Wnt

P59665

Interaction Score

0.927

B3KQX9

(UniProtKB/TrEmbl/P) Details

Protein Wnt

P59665

Interaction Score

0.911

Q7Z3T9

(UniProtKB/TrEmbl/P) Details

Neuropilin

P59665

Interaction Score

0.871

P34059

(UniProtKB/Swiss-Prot/P) Details

N-acetylgalactosamine-6-sulfatase

P59665

Interaction Score

0.848

A0A0A6YYF2

(UniProtKB/TrEmbl/P) Details

HCG1811249, isoform CRA_e

P59665

Interaction Score

0.838

Q96QC4

(UniProtKB/TrEmbl/P) Details

MHC class I polypeptide-related sequence A, isoform CRA_c

P59665

Interaction Score

0.823

Q01459

(UniProtKB/Swiss-Prot/P) Details

Di-N-acetylchitobiase

P59665

Interaction Score

0.812

J3KNV4

(UniProtKB/TrEmbl/P) Details

Integrin alpha-7

P59665

Interaction Score

0.798

A0A0S2Z4C6

(UniProtKB/TrEmbl/P) Details

Serine/threonine-protein phosphatase

P59665

Interaction Score

0.798

A0A024R931

(UniProtKB/TrEmbl/P) Details

alpha-1,2-Mannosidase

P59665

Interaction Score

0.798

B7Z2I3

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

P59665

Interaction Score

0.798

E7BSV0

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

P59665

Interaction Score

0.798

F2YGG7

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

P59665

Interaction Score

0.768

H0YM98

(UniProtKB/TrEmbl/P) Details

Cholinergic receptor, nicotinic, alpha 5, isoform CRA_b

P59665

Interaction Score

0.743

O60925

(UniProtKB/Swiss-Prot/P) Details

Prefoldin subunit 1

P59665

Interaction Score

0.742

P16298

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

P59665

Interaction Score

0.742

Q9BTE3

(UniProtKB/Swiss-Prot/P) Details

Mini-chromosome maintenance complex-binding protein

P59665

Interaction Score

0.728

Q9UIU0

(UniProtKB/TrEmbl/P) Details

Dihydropyridine receptor alpha 2 subunit

P59665

Interaction Score

0.728

Q4LE35

(UniProtKB/TrEmbl/P) Details

ITGA7 variant protein

P59665

Interaction Score

0.722

C9JMY1

(UniProtKB/TrEmbl/P) Details

Insulin-like growth factor-binding protein 2

P59665

Interaction Score

0.722

A0A0A0MSA0

(UniProtKB/TrEmbl/P) Details

Laminin subunit alpha-3

P59665

Interaction Score

0.722

A0A0A0MTS5

(UniProtKB/TrEmbl/P) Details

HCG1811249, isoform CRA_f

P59665

Interaction Score

0.716

G3V1L9

(UniProtKB/TrEmbl/P) Details

Tight junction protein 1 (Zona occludens 1), isoform CRA_a

P59665

Interaction Score

0.713

Q9BT09

(UniProtKB/Swiss-Prot/P) Details

Protein canopy homolog 3

P59665

Interaction Score

0.64

G5E9E7

(UniProtKB/TrEmbl/P) Details

Tight junction protein 1 (Zona occludens 1), isoform CRA_e

P59665

Interaction Score

0.64

Q6EWN4

(UniProtKB/TrEmbl/P) Details

Neuronal nicotinic acetylcholine receptor, alpha5 subunit

P59665

Interaction Score

0.64

Q59H02

(UniProtKB/TrEmbl/P) Details

Suppression of tumorigenicity variant

P59665

Interaction Score

0.631

F8WAQ1

(UniProtKB/TrEmbl/P) Details

Sushi domain-containing protein 1

P59665

Interaction Score

0.631

Q4G0X5

(UniProtKB/TrEmbl/P) Details

E3 ubiquitin-protein ligase E3D

P59665

Interaction Score

0.631

Q8TAS6

(UniProtKB/TrEmbl/P) Details

LAMB1 protein

P59665

Interaction Score

0.56

Q6MZP1

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp686D20222

P59665

Interaction Score

0.468

O00462

(UniProtKB/Swiss-Prot/P) Details

Beta-mannosidase

P59665

Interaction Score

0.3

Q9UKT5

(UniProtKB/Swiss-Prot/P) Details

F-box only protein 4

P59665

Interaction Score

0.299

Q3LXA3

(UniProtKB/Swiss-Prot/P) Details

Triokinase/FMN cyclase

P59665

Interaction Score

0.299

P48454

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

P59665

Interaction Score

0.282

Q99708

(UniProtKB/Swiss-Prot/P) Details

DNA endonuclease RBBP8

P59665

Interaction Score

0.282

Q8TC97

(UniProtKB/TrEmbl/P) Details

CTBS protein

P59665

Interaction Score

0.282

Q6YL38

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein

P59665

Interaction Score

0.282

Q96I49

(UniProtKB/TrEmbl/P) Details

GALNS protein

P59665

Interaction Score

0.258

Q7Z6J8

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase E3D

P59665

Interaction Score

0.24

C9JE82

(UniProtKB/TrEmbl/P) Details

Voltage-dependent calcium channel subunit alpha-2/delta-2

P59665

Interaction Score

0.24

Q53XC6

(UniProtKB/TrEmbl/P) Details

Full-length cDNA clone CS0DI011YN22 of Placenta of Homo sapiens

P59665

Interaction Score

0.24

Q96CY7

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein

P59665

Interaction Score

0.24

B4DN26

(UniProtKB/TrEmbl/P) Details

cDNA FLJ59355, highly similar to Tissue-type plasminogen activator

P59665

Interaction Score

0.21

Q6MZU1

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp686A1195

P59665

Interaction Score

Q6FI27

(UniProtKB/TrEmbl/P) Details

GSK3B protein

P59665

Interaction Score

D6RAJ6

(UniProtKB/TrEmbl/P) Details

F-box only protein 4

P59665

Interaction Score

P17020

(UniProtKB/Swiss-Prot/P) Details

Zinc finger protein 16

⇦ Back to the Search Page
⇦ Back to Starting Page

P59665

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P59665

P01137

Transforming growth factor beta-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665

Q9Y4K0

Lysyl oxidase homolog 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665

P23142

Fibulin-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665

P18065

Insulin-like growth factor-binding protein 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665

P41221

Protein Wnt-5a

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665

Q03167

Transforming growth factor beta receptor type 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665

Q9NZ08

Endoplasmic reticulum aminopeptidase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665

Q16787

Laminin subunit alpha-3

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665

O15230

Laminin subunit alpha-5

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665

P07942

Laminin subunit beta-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665

Q92626

Peroxidasin homolog

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665

P12109

Collagen alpha-1(VI) chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P59665