Q03167

Transforming growth factor beta receptor type 3 // UniProt Profile

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Species	H. sapiens
Number of Interactions	42 / 49
Average Interaction Score	0.955

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.8	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.657	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.657	Unknown: unspecified method	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.999	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Inhibin-betaglycan-ActRII complex (GO:0034673)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.657	Unknown: HDA	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q03167

Interaction Score

P01137

(UniProtKB/Swiss-Prot/P) Details

Transforming growth factor beta-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.853	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.996	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.98	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.98	Unknown: unspecified method	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	0.853	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.853	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.98	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Microvillus (GO:0005902)	0.996	Experimental: inferred from direct assay	GO	PubMed
Membrane	Axon (GO:0030424)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.999	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.999	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.996	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.996	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

BioGRID, DIP, HPRD, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q03167

Interaction Score

Q9Y287

(UniProtKB/Swiss-Prot/P) Details

Integral membrane protein 2B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.994	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.996	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi-associated vesicle membrane (GO:0030660)	0.996	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.992	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.999	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Integral to organelle membrane (GO:0031301)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.994	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q03167

Interaction Score

P34741

(UniProtKB/Swiss-Prot/P) Details

Syndecan-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.51	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	0.51	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosomal lumen (GO:0043202)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.988	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.988	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.988	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q03167

Interaction Score

O14786

(UniProtKB/Swiss-Prot/P) Details

Neuropilin-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.937	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Semaphorin receptor complex (GO:0002116)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Cell surface (GO:0009986)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.86	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: unspecified method	The Human Protein Atlas	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.937	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.937	Unknown: traceable author statement	GO	PubMed
Membrane	Growth cone (GO:0030426)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuron projection (GO:0043005)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Axon (GO:0030424)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Neurofilament (GO:0005883)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.958	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q03167

Interaction Score

O14908

(UniProtKB/Swiss-Prot/P) Details

PDZ domain-containing protein GIPC1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cell cortex (GO:0005938)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.958	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endocytic vesicle (GO:0030139)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Synaptic vesicle (GO:0008021)	0.958	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Brush border (GO:0005903)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendritic shaft (GO:0043198)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane (GO:0016020)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Cytosol	Vesicle membrane (GO:0012506)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

HPRD, IntAct

Interaction Source Publication:

PubMed

Q03167

Interaction Score

P17813

(UniProtKB/Swiss-Prot/P) Details

Endoglin

Q03167

Interaction Score

P37173

(UniProtKB/Swiss-Prot/P) Details

TGF-beta receptor type-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.3	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane raft (GO:0045121)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Caveola (GO:0005901)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Transforming growth factor beta receptor complex (GO:0070022)	1	Unknown: inferred by curator	GO	PubMed

Interaction Source Database:

DIP, BioGRID, HPRD

Interaction Source Publication:

PubMed

, PubMed

Q03167

Interaction Score

Q13635

(UniProtKB/Swiss-Prot/P) Details

Protein patched homolog 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.972	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.972	Unknown: traceable author statement	GO	PubMed
Membrane	Dendritic growth cone (GO:0044294)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axonal growth cone (GO:0044295)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cilium membrane (GO:0060170)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Caveola (GO:0005901)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q03167

Interaction Score

Q99755

(UniProtKB/Swiss-Prot/P) Details

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	MRNA cleavage and polyadenylation specificity factor complex (GO:0005847)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.8	Experimental: experimental	eSLDB	PubMed
Membrane	Ruffle membrane (GO:0032587)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q03167

Interaction Score

P54709

(UniProtKB/Swiss-Prot/P) Details

Sodium/potassium-transporting ATPase subunit beta-3

Q03167

Interaction Score

P61812

(UniProtKB/Swiss-Prot/P) Details

Transforming growth factor beta-2

Q03167

Interaction Score

P11362

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor receptor 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Unknown: non-traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.999	Unknown: traceable author statement	GO	PubMed
Membrane	Receptor complex (GO:0043235)	0.999	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q03167

Interaction Score

P10600

(UniProtKB/Swiss-Prot/P) Details

Transforming growth factor beta-3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.86	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.996	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.996	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.996	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.996	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.996	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.931	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.931	Unknown: inferred by curator	GO	PubMed
Membrane	T-tubule (GO:0030315)	0.931	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct, HPRD

Interaction Source Publication:

PubMed

, PubMed

Q03167

Interaction Score

P05230

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.958	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.958	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cell cortex (GO:0005938)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.999	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q03167

Interaction Score

P27037

(UniProtKB/Swiss-Prot/P) Details

Activin receptor type-2A

Q03167

Interaction Score

Q8WVQ1

(UniProtKB/Swiss-Prot/P) Details

Soluble calcium-activated nucleotidase 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.902	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.86	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi cisterna membrane (GO:0032580)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.996	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.996	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.996	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.86	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q03167

Interaction Score

P05111

(UniProtKB/Swiss-Prot/P) Details

Inhibin alpha chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.8	Experimental: experimental	eSLDB	PubMed
Membrane	Photoreceptor inner segment (GO:0001917)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.902	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Photoreceptor outer segment (GO:0001750)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Inhibin A complex (GO:0043512)	0.958	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.98	Experimental: experimental	MatrixDB	PubMed
Membrane	Inhibin-betaglycan-ActRII complex (GO:0034673)	0.98	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q03167

Interaction Score

P32121

(UniProtKB/Swiss-Prot/P) Details

Beta-arrestin-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Coated pit (GO:0005905)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.972	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endocytic vesicle (GO:0030139)	0.972	Experimental: inferred from direct assay	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	0.99	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	0.99	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.99	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.99	Experimental: experimental	Organelle	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	0.99	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic membrane (GO:0045211)	0.99	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q03167

Interaction Score

P32249

(UniProtKB/Swiss-Prot/P) Details

G-protein coupled receptor 183

Q03167

Interaction Score

P59665

(UniProtKB/Swiss-Prot/P) Details

Neutrophil defensin 1

Q03167

Interaction Score

P08476

(UniProtKB/Swiss-Prot/P) Details

Inhibin beta A chain

Q03167

Interaction Score

0.998

Q9UN42

(UniProtKB/Swiss-Prot/P) Details

Protein ATP1B4

Q03167

Interaction Score

0.995

Q9UK85

(UniProtKB/Swiss-Prot/P) Details

Dickkopf-like protein 1

Q03167

Interaction Score

0.994

Q92187

(UniProtKB/Swiss-Prot/P) Details

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

Q03167

Interaction Score

0.992

Q8NCB2

(UniProtKB/Swiss-Prot/P) Details

CaM kinase-like vesicle-associated protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular (GO:0005622)	0.998	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Cytoplasmic vesicle membrane (GO:0030659)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	MatrixDB	PubMed
Extracellular	Intercellular bridge (GO:0045171)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Plasma membrane (GO:0005886)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q03167

Interaction Score

0.992

Q01523

(UniProtKB/Swiss-Prot/P) Details

Defensin-5

Q03167

Interaction Score

0.988

Q9UBX7

(UniProtKB/Swiss-Prot/P) Details

Kallikrein-11

Q03167

Interaction Score

0.952

Q15717

(UniProtKB/Swiss-Prot/P) Details

ELAV-like protein 1

Q03167

Interaction Score

0.951

Q9HAT2

(UniProtKB/Swiss-Prot/P) Details

Sialate O-acetylesterase

Q03167

Interaction Score

0.95

Q96LR4

(UniProtKB/Swiss-Prot/P) Details

Protein FAM19A4

Q03167

Interaction Score

0.94

Q16089

(UniProtKB/TrEmbl/P) Details

Fibroblast growth factor 1

Q03167

Interaction Score

0.94

A3QNQ0

(UniProtKB/TrEmbl/P) Details

TGF-beta receptor type-2

Q03167

Interaction Score

0.933

Q5JR98

(UniProtKB/Swiss-Prot/P) Details

Tctex1 domain-containing protein 4

Q03167

Interaction Score

0.929

Q6AWA9

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp686A03134

Q03167

Interaction Score

0.912

Q68DN3

(UniProtKB/TrEmbl/P) Details

Neuropilin

Q03167

Interaction Score

0.905

A6PW57

(UniProtKB/TrEmbl/P) Details

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Q03167

Interaction Score

0.8

A8K147

(UniProtKB/TrEmbl/P) Details

Multifunctional fusion protein

Q03167

Interaction Score

0.799

D2JYI1

(UniProtKB/TrEmbl/P) Details

TGF-beta receptor type-2

Q03167

Interaction Score

0.799

A0A0S2Z3Q6

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Q03167

Interaction Score

0.799

A8K9V7

(UniProtKB/TrEmbl/P) Details

Neuropilin

Q03167

Interaction Score

0.799

Q6X907

(UniProtKB/TrEmbl/P) Details

Neuropilin

Q03167

Interaction Score

0.752

Q59F20

(UniProtKB/TrEmbl/P) Details

Neuropilin-1 variant

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Q03167

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q03167

P01137

Transforming growth factor beta-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167

Q9Y287

Integral membrane protein 2B

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167

P34741

Syndecan-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167

O14786

Neuropilin-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167

O14908

PDZ domain-containing protein GIPC1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167

P17813

Endoglin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167

P37173

TGF-beta receptor type-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167

Q13635

Protein patched homolog 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167

Q99755

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167

P54709

Sodium/potassium-transporting ATPase subunit beta-3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167

P61812

Transforming growth factor beta-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167

P11362

Fibroblast growth factor receptor 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q03167