Q8N668

COMM domain-containing protein 1 // UniProt Profile

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Species	H. sapiens
Number of Interactions	114 / 160
Average Interaction Score	0.897

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cul2-RING ubiquitin ligase complex (GO:0031462)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Recycling endosome (GO:0055037)	0.972	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.972	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed

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Interactions

All Details

Q8N668

Interaction Score

P55072

(UniProtKB/Swiss-Prot/P) Details

Transitional endoplasmic reticulum ATPase

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lipid particle (GO:0005811)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasmic stress granule (GO:0010494)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Proteasome complex (GO:0000502)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Cdc48p-Npl4p-Ufd1p AAA ATPase complex (GO:0034098)	0.994	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.994	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Azurophil granule lumen (GO:0035578)	0.994	Unknown: traceable author statement	GO	PubMed
Nucleus	Site of double-strand break (GO:0035861)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.3	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

P00441

(UniProtKB/Swiss-Prot/P) Details

Superoxide dismutase [Cu-Zn]

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.902	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial matrix (GO:0005759)	0.902	Unknown: non-traceable author statement	GO	PubMed
Mitochondrion	Mitochondrial intermembrane space (GO:0005758)	0.902	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Peroxisome (GO:0005777)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.86	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Dense core granule (GO:0031045)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendrite cytoplasm (GO:0032839)	0.999	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.994	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

O60260

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase parkin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	LUBAC complex (GO:0071797)	1	Predicted: inferred from physical interaction	GO	PubMed
Cytosol	SCF ubiquitin ligase complex (GO:0019005)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Aggresome (GO:0016235)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: inferred from mutant phenotype	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.96	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Neuron projection (GO:0043005)	0.8	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.7	Predicted: pTarget method	LOCATE	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

P10909

(UniProtKB/Swiss-Prot/P) Details

Clusterin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular (GO:0005622)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
N/A	Neurofibrillary tangle (GO:0097418)	0.8	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.86	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial membrane (GO:0031966)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.992	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.897	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.897	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.897	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Chromaffin granule (GO:0042583)	0.897	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Cell periphery (GO:0071944)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical dendrite (GO:0097440)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	1	Unknown: HDA	GO	PubMed
Extracellular	Spherical high-density lipoprotein particle (GO:0034366)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Synapse (GO:0045202)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

P31749

(UniProtKB/Swiss-Prot/P) Details

RAC-alpha serine/threonine-protein kinase

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Spindle (GO:0005819)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cilium basal body (GO:0036064)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.86	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Vesicle (GO:0031982)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	0.86	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

Q04206

(UniProtKB/Swiss-Prot/P) Details

Transcription factor p65

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	I-kappaB/NF-kappaB complex (GO:0033256)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Transcription factor complex (GO:0005667)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromatin (GO:0000790)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q8N668

Interaction Score

Q13618

(UniProtKB/Swiss-Prot/P) Details

Cullin-3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cul3-RING ubiquitin ligase complex (GO:0031463)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.937	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.86	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Polar microtubule (GO:0005827)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Sperm flagellum (GO:0036126)	0.86	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

O00141

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase Sgk1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.996	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.996	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.996	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.996	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

P19838

(UniProtKB/Swiss-Prot/P) Details

Nuclear factor NF-kappa-B p105 subunit

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	I-kappaB/NF-kappaB complex (GO:0033256)	0.998	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.3	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.3	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

Q00653

(UniProtKB/Swiss-Prot/P) Details

Nuclear factor NF-kappa-B p100 subunit

Q8N668

Interaction Score

Q9H267

(UniProtKB/Swiss-Prot/P) Details

Vacuolar protein sorting-associated protein 33B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Recycling endosome (GO:0055037)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Late endosome membrane (GO:0031902)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	HOPS complex (GO:0030897)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Platelet alpha granule (GO:0031091)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Clathrin-coated vesicle (GO:0030136)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Clathrin complex (GO:0071439)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	AP-3 adaptor complex (GO:0030123)	0.96	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

Q01201

(UniProtKB/Swiss-Prot/P) Details

Transcription factor RelB

Q8N668

Interaction Score

Q9P000

(UniProtKB/Swiss-Prot/P) Details

COMM domain-containing protein 9

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.988	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.988	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.972	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.972	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.3	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

Q13489

(UniProtKB/Swiss-Prot/P) Details

Baculoviral IAP repeat-containing protein 3

Q8N668

Interaction Score

Q9UBQ0

(UniProtKB/Swiss-Prot/P) Details

Vacuolar protein sorting-associated protein 29

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Retromer complex (GO:0030904)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Retromer complex, inner shell (GO:0030906)	1	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.986	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.986	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

P38398

(UniProtKB/Swiss-Prot/P) Details

Breast cancer type 1 susceptibility protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	0.996	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Ubiquitin ligase complex (GO:0000151)	0.996	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.996	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	BRCA1-A complex (GO:0070531)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	BRCA1-BARD1 complex (GO:0031436)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.996	Experimental: experimental	Organelle	PubMed
Cytosol	Gamma-tubulin ring complex (GO:0008274)	0.996	Unknown: non-traceable author statement	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Lateral element (GO:0000800)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.8	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

P25963

(UniProtKB/Swiss-Prot/P) Details

NF-kappa-B inhibitor alpha

Q8N668

Interaction Score

P13569

(UniProtKB/Swiss-Prot/P) Details

Cystic fibrosis transmembrane conductance regulator

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.972	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.94	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum Sec complex (GO:0031205)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi-associated vesicle membrane (GO:0030660)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Recycling endosome (GO:0055037)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.972	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin coated vesicle membrane (GO:0030665)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Chloride channel complex (GO:0034707)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

Q16665

(UniProtKB/Swiss-Prot/P) Details

Hypoxia-inducible factor 1-alpha

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.992	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Transcription factor complex (GO:0005667)	1	Predicted: inferred from physical interaction	GO	PubMed
Nucleus	RNA polymerase II transcription factor complex (GO:0090575)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Membrane	Motile cilium (GO:0031514)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

O60343

(UniProtKB/Swiss-Prot/P) Details

TBC1 domain family member 4

Q8N668

Interaction Score

O95990

(UniProtKB/Swiss-Prot/P) Details

Protein FAM107A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.988	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.988	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Stress fiber (GO:0001725)	0.988	Experimental: inferred from direct assay	GO	PubMed
Membrane	Ruffle membrane (GO:0032587)	0.996	Experimental: inferred from direct assay	GO	PubMed
Membrane	Neuron projection (GO:0043005)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.996	Experimental: inferred from direct assay	GO	PubMed
Membrane	Synapse (GO:0045202)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

Q14258

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin/ISG15 ligase TRIM25

Q8N668

Interaction Score

Q9UNY4

(UniProtKB/Swiss-Prot/P) Details

Transcription termination factor 2

Q8N668

Interaction Score

Q13620

(UniProtKB/Swiss-Prot/P) Details

Cullin-4B

Q8N668

Interaction Score

Q13616

(UniProtKB/Swiss-Prot/P) Details

Cullin-1

Q8N668

Interaction Score

P11413

(UniProtKB/Swiss-Prot/P) Details

Glucose-6-phosphate 1-dehydrogenase

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.7	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Unknown: HDA	GO	PubMed
Membrane	Internal side of plasma membrane (GO:0009898)	0.86	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

Q8N4N8

(UniProtKB/Swiss-Prot/P) Details

Kinesin-like protein KIF2B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleolus (GO:0005730)	0.902	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.902	Unknown: unspecified method	The Human Protein Atlas	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	0.999	Unknown: unspecified method	The Human Protein Atlas	PubMed
Cytosol	Mitotic spindle (GO:0072686)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Kinesin complex (GO:0005871)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Microtubule (GO:0005874)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Condensed chromosome kinetochore (GO:0000777)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Intercellular bridge (GO:0045171)	0.86	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Intercellular bridge (GO:0045171)	0.86	Unknown: unspecified method	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

Q04656

(UniProtKB/Swiss-Prot/P) Details

Copper-transporting ATPase 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell leading edge (GO:0031252)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.994	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Perikaryon (GO:0043204)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.994	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Trans-Golgi network (GO:0005802)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Secretory granule (GO:0030141)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Trans-Golgi network transport vesicle (GO:0030140)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Membrane	Microvillus (GO:0005902)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Brush border membrane (GO:0031526)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuron projection (GO:0043005)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane raft (GO:0045121)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

Q92830

(UniProtKB/Swiss-Prot/P) Details

Histone acetyltransferase KAT2A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Oxoglutarate dehydrogenase complex (GO:0045252)	0.972	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Transcription factor TFTC complex (GO:0033276)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Ada2/Gcn5/Ada3 transcription activator complex (GO:0005671)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	STAGA complex (GO:0030914)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Mitotic spindle (GO:0072686)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.972	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromatin (GO:0000790)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.3	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

P98170

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase XIAP

Q8N668

Interaction Score

Q14999

(UniProtKB/Swiss-Prot/P) Details

Cullin-7

Q8N668

Interaction Score

Q14186

(UniProtKB/Swiss-Prot/P) Details

Transcription factor Dp-1

Q8N668

Interaction Score

O60216

(UniProtKB/Swiss-Prot/P) Details

Double-strand-break repair protein rad21 homolog

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.86	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.86	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nuclear matrix (GO:0016363)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Chromosome (GO:0005694)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear cohesin complex (GO:0000798)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Chromatin (GO:0000785)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Chromosome, centromeric region (GO:0000775)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Cohesin complex (GO:0008278)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

P42771

(UniProtKB/Swiss-Prot/P) Details

Cyclin-dependent kinase inhibitor 2A

Q8N668

Interaction Score

Q9GZQ3

(UniProtKB/Swiss-Prot/P) Details

COMM domain-containing protein 5

Q8N668

Interaction Score

P49917

(UniProtKB/Swiss-Prot/P) Details

DNA ligase 4

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.94	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Nonhomologous end joining complex (GO:0070419)	0.94	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	DNA ligase IV complex (GO:0032807)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Nucleus	DNA-dependent protein kinase-DNA ligase 4 complex (GO:0005958)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nuclear chromosome, telomeric region (GO:0000784)	1	Unknown: inferred by curator	GO	PubMed
Nucleus	Condensed chromosome (GO:0000793)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

P0CG48

(UniProtKB/Swiss-Prot/P) Details

Polyubiquitin-C

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.969	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.969	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytosol (GO:0005829)	0.969	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrial outer membrane (GO:0005741)	0.3	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.956	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.956	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.956	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.956	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.657	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.657	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.657	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.902	Experimental: experimental	MatrixDB	PubMed
Extracellular	Host cell (GO:0043657)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.902	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.902	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.902	Unknown: traceable author statement	GO	PubMed
Cytosol	Vesicle (GO:0031982)	0.969	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.969	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

P11274

(UniProtKB/Swiss-Prot/P) Details

Breakpoint cluster region protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.971	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.971	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.971	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.988	Experimental: inferred from direct assay	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	0.956	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.956	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.971	Unknown: HDA	GO	PubMed
Membrane	Cell junction (GO:0030054)	0.956	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic membrane (GO:0045211)	0.956	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

Q9NX08

(UniProtKB/Swiss-Prot/P) Details

COMM domain-containing protein 8

Q8N668

Interaction Score

Q13619

(UniProtKB/Swiss-Prot/P) Details

Cullin-4A

Q8N668

Interaction Score

P34932

(UniProtKB/Swiss-Prot/P) Details

Heat shock 70 kDa protein 4

Q8N668

Interaction Score

Q93034

(UniProtKB/Swiss-Prot/P) Details

Cullin-5

Q8N668

Interaction Score

Q99728

(UniProtKB/Swiss-Prot/P) Details

BRCA1-associated RING domain protein 1

Q8N668

Interaction Score

O15524

(UniProtKB/Swiss-Prot/P) Details

Suppressor of cytokine signaling 1

Q8N668

Interaction Score

Q09472

(UniProtKB/Swiss-Prot/P) Details

Histone acetyltransferase p300

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Transcription factor complex (GO:0005667)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Histone acetyltransferase complex (GO:0000123)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Protein-DNA complex (GO:0032993)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

0.999

Q9H0A8

(UniProtKB/Swiss-Prot/P) Details

COMM domain-containing protein 4

Q8N668

Interaction Score

0.999

Q96NL6

(UniProtKB/Swiss-Prot/P) Details

Sodium channel and clathrin linker 1

Q8N668

Interaction Score

0.999

O75461

(UniProtKB/Swiss-Prot/P) Details

Transcription factor E2F6

Q8N668

Interaction Score

0.999

Q04864

(UniProtKB/Swiss-Prot/P) Details

Proto-oncogene c-Rel

Q8N668

Interaction Score

0.999

Q567U6

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 93

Q8N668

Interaction Score

0.999

Q13617

(UniProtKB/Swiss-Prot/P) Details

Cullin-2

Q8N668

Interaction Score

0.999

Q96BW1

(UniProtKB/Swiss-Prot/P) Details

Uracil phosphoribosyltransferase homolog

Q8N668

Interaction Score

0.999

O60826

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 22

Q8N668

Interaction Score

0.998

P35670

(UniProtKB/Swiss-Prot/P) Details

Copper-transporting ATPase 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.8	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network (GO:0005802)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.998	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.998	Unknown: traceable author statement	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	0.998	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

0.998

Q9HBL8

(UniProtKB/Swiss-Prot/P) Details

NmrA-like family domain-containing protein 1

Q8N668

Interaction Score

0.998

Q9P281

(UniProtKB/Swiss-Prot/P) Details

BAH and coiled-coil domain-containing protein 1

Q8N668

Interaction Score

0.998

Q13952

(UniProtKB/Swiss-Prot/P) Details

Nuclear transcription factor Y subunit gamma

Q8N668

Interaction Score

0.997

Q86VX2

(UniProtKB/Swiss-Prot/P) Details

COMM domain-containing protein 7

Q8N668

Interaction Score

0.997

P10451

(UniProtKB/Swiss-Prot/P) Details

Osteopontin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.998	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Cell projection (GO:0042995)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.992	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.992	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.51	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

0.997

Q86X83

(UniProtKB/Swiss-Prot/P) Details

COMM domain-containing protein 2

Q8N668

Interaction Score

0.997

P51170

(UniProtKB/Swiss-Prot/P) Details

Amiloride-sensitive sodium channel subunit gamma

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Sodium channel complex (GO:0034706)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.8	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

0.996

Q15369

(UniProtKB/Swiss-Prot/P) Details

Elongin-C

Q8N668

Interaction Score

0.995

Q8N1F8

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase 11-interacting protein

Q8N668

Interaction Score

0.994

Q8IYN2

(UniProtKB/Swiss-Prot/P) Details

Transcription elongation factor A protein-like 8

Q8N668

Interaction Score

0.992

Q13075

(UniProtKB/Swiss-Prot/P) Details

Baculoviral IAP repeat-containing protein 1

Q8N668

Interaction Score

0.991

E9PJ95

(UniProtKB/TrEmbl/P) Details

COMM domain-containing protein 9

Q8N668

Interaction Score

0.99

Q9Y6G5

(UniProtKB/Swiss-Prot/P) Details

COMM domain-containing protein 10

Q8N668

Interaction Score

0.99

Q8N726

(UniProtKB/Swiss-Prot/P) Details

Tumor suppressor ARF

Q8N668

Interaction Score

0.988

Q8TCE6

(UniProtKB/Swiss-Prot/P) Details

Protein FAM45A

Q8N668

Interaction Score

0.987

Q309B1

(UniProtKB/Swiss-Prot/P) Details

Tripartite motif-containing protein 16-like protein

Q8N668

Interaction Score

0.985

P51172

(UniProtKB/Swiss-Prot/P) Details

Amiloride-sensitive sodium channel subunit delta

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Actin cytoskeleton (GO:0015629)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q8N668

Interaction Score

0.981

Q53YM3

(UniProtKB/TrEmbl/P) Details

E2F transcription factor 6, isoform CRA_d

Q8N668

Interaction Score

0.981

Q6Q9Z5

(UniProtKB/TrEmbl/P) Details

E2F6 splice variant f

Q8N668

Interaction Score

0.973

Q5T2N8

(UniProtKB/Swiss-Prot/P) Details

ATPase family AAA domain-containing protein 3C

Q8N668

Interaction Score

0.96

D6RBA6

(UniProtKB/TrEmbl/P) Details

Sodium channel and clathrin linker 1

Q8N668

Interaction Score

0.96

F8VXU5

(UniProtKB/TrEmbl/P) Details

Vacuolar protein sorting-associated protein 29

Q8N668

Interaction Score

0.96

D6R992

(UniProtKB/TrEmbl/P) Details

Transcription factor RelB

Q8N668

Interaction Score

0.954

Q7Z4G1

(UniProtKB/Swiss-Prot/P) Details

COMM domain-containing protein 6

Q8N668

Interaction Score

0.952

Q9UBI1

(UniProtKB/Swiss-Prot/P) Details

COMM domain-containing protein 3

Q8N668

Interaction Score

0.949

P55011

(UniProtKB/Swiss-Prot/P) Details

Solute carrier family 12 member 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.86	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8N668

Interaction Score

0.949

P51168

(UniProtKB/Swiss-Prot/P) Details

Amiloride-sensitive sodium channel subunit beta

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Cytoplasmic vesicle membrane (GO:0030659)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Sodium channel complex (GO:0034706)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.8	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q8N668

Interaction Score

0.94

A6NNF7

(UniProtKB/TrEmbl/P) Details

Amiloride-sensitive sodium channel subunit delta

Q8N668

Interaction Score

0.939

A0A0A0MR50

(UniProtKB/TrEmbl/P) Details

Cullin-4A

Q8N668

Interaction Score

0.939

F8WBW8

(UniProtKB/TrEmbl/P) Details

BAH and coiled-coil domain-containing protein 1

Q8N668

Interaction Score

0.938

K4DI93

(UniProtKB/TrEmbl/P) Details

Cullin 4B, isoform CRA_e

Q8N668

Interaction Score

0.932

O14972

(UniProtKB/Swiss-Prot/P) Details

Down syndrome critical region protein 3

Q8N668

Interaction Score

0.923

Q7Z3J2

(UniProtKB/Swiss-Prot/P) Details

UPF0505 protein C16orf62

Q8N668

Interaction Score

0.909

Q53FR9

(UniProtKB/TrEmbl/P) Details

COMM domain containing 9 variant

Q8N668

Interaction Score

0.908

A0AVN2

(UniProtKB/TrEmbl/P) Details

BRCA1 associated RING domain 1

Q8N668

Interaction Score

0.908

Q7Z6C1

(UniProtKB/TrEmbl/P) Details

EP300 protein

Q8N668

Interaction Score

0.8

A0A087X0W8

(UniProtKB/TrEmbl/P) Details

Transcription factor p65

Q8N668

Interaction Score

0.798

A0A0A0MTN0

(UniProtKB/TrEmbl/P) Details

Cullin-2

Q8N668

Interaction Score

0.798

E9PR89

(UniProtKB/TrEmbl/P) Details

Non-specific serine/threonine protein kinase

Q8N668

Interaction Score

0.798

G3XAG3

(UniProtKB/TrEmbl/P) Details

Cyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4), isoform CRA_a

Q8N668

Interaction Score

0.798

A0A0B4J287

(UniProtKB/TrEmbl/P) Details

COMM domain-containing protein 4

Q8N668

Interaction Score

0.798

H3BQF2

(UniProtKB/TrEmbl/P) Details

COMM domain-containing protein 4

Q8N668

Interaction Score

0.798

A0A087WZ19

(UniProtKB/TrEmbl/P) Details

BRCA1-associated RING domain protein 1

Q8N668

Interaction Score

0.798

A0A087X2H0

(UniProtKB/TrEmbl/P) Details

BRCA1-associated RING domain protein 1

Q8N668

Interaction Score

0.798

F6MDI1

(UniProtKB/TrEmbl/P) Details

BRCA1 associated RING domain 1 isoform delta

Q8N668

Interaction Score

0.798

A0A0C4DGV9

(UniProtKB/TrEmbl/P) Details

DNA ligase

Q8N668

Interaction Score

0.798

Q6IAM1

(UniProtKB/TrEmbl/P) Details

Family with sequence similarity 107 member A transcript variant

Q8N668

Interaction Score

0.778

B7ZLR4

(UniProtKB/TrEmbl/P) Details

ATP7B protein

Q8N668

Interaction Score

0.778

E7ET55

(UniProtKB/TrEmbl/P) Details

Copper-transporting ATPase 2

Q8N668

Interaction Score

0.7

Q96KS9

(UniProtKB/Swiss-Prot/P) Details

Protein FAM167A

Q8N668

Interaction Score

0.698

Q4JHT5

(UniProtKB/TrEmbl/P) Details

cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1

Q8N668

Interaction Score

0.698

E7EWW0

(UniProtKB/TrEmbl/P) Details

VPS35 endosomal protein sorting factor-like

Q8N668

Interaction Score

0.64

A0A024R730

(UniProtKB/TrEmbl/P) Details

Cystic fibrosis transmembrane conductance regulator

Q8N668

Interaction Score

0.3

D6RJ90

(UniProtKB/TrEmbl/P) Details

COMM domain containing 10, isoform CRA_b

Q8N668

Interaction Score

V9HWC9

(UniProtKB/TrEmbl/P) Details

Superoxide dismutase [Cu-Zn]

Q8N668

Interaction Score

Q762B6

(UniProtKB/TrEmbl/P) Details

ATP7A protein

Q8N668

Interaction Score

Q53ZR1

(UniProtKB/TrEmbl/P) Details

Bumetanide-sensitive Na-K-Cl cotransporter

Q8N668

Interaction Score

F5H7K1

(UniProtKB/TrEmbl/P) Details

VPS35 endosomal protein sorting factor-like

Q8N668

Interaction Score

A8MTY9

(UniProtKB/TrEmbl/P) Details

VPS26 endosomal protein sorting factor C

Q8N668

Interaction Score

A8MY26

(UniProtKB/TrEmbl/P) Details

VPS26 endosomal protein sorting factor C

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Q8N668

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q8N668

P55072

Transitional endoplasmic reticulum ATPase

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8N668

P00441

Superoxide dismutase [Cu-Zn]

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8N668

O60260

E3 ubiquitin-protein ligase parkin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8N668

P10909

Clusterin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8N668

P31749

RAC-alpha serine/threonine-protein kinase

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Q8N668

Q04206

Transcription factor p65

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Q8N668

Q13618

Cullin-3

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Q8N668

O00141

Serine/threonine-protein kinase Sgk1

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Q8N668

P19838

Nuclear factor NF-kappa-B p105 subunit

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Q8N668

Q00653

Nuclear factor NF-kappa-B p100 subunit

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Q8N668

Q9H267

Vacuolar protein sorting-associated protein 33B

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Q8N668

Q01201

Transcription factor RelB

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Q8N668